Registration Dossier
Registration Dossier
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EC number: 216-374-5 | CAS number: 1569-02-4
Endpoint summary
Administrative data
Description of key information
Additional information
The available aquatic toxicology data for ethoxypropanol are summarized below. The available direct and indirect evidence consistently indicate that ethoxypropanol is of low acute toxicity to aquatic organisms and that algae are the most sensitive trophic level. This trend is clearly indicated by the predictions of a QSAR and is strongly supported by the available evidence from measured data, which is principally available from read across substances, although it should be noted that the differences between toxicity to the threee trophic levels is actually quite small and consistent with the mode of action being that of non-polar narcosis. The structure is consistent with substances likely to act by this mode (Verhaar, 1992). Non-polar narcosis is rapidly and completely reversible and is correlated with lipophilicity rather than any specific chemical property (Shultz, 1989). The data from algae are taken forward as the critical end point from which to derive the PNEC. A reliable algal toxicity study is available for ethoxypropanol but this is only a limit study carried out for classification and labelling purposes. It does not provide useful information for derivation of the PNEC. Therefore data from a read across substance propoxypropanol (propylene glycol propyl ether) is used. This is a conservative approach as the latter would be predicted to be more toxic than the former.
References
Shultz TW (1989) “Non polar narcosis. A review of the mechanism of action for baseline toxicity.” Aquatic Toxicology and Hazard Assessment, 12th vol, ASTM STP1027, ed Cowgill & Williams, p104-9.
Verhaar HJM et al (1992) “Classifying environmental pollutants. 1. Structure-activity relationships for prediction of aquatic toxicity”. Chemosphere 25, 4, 471-91.
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