Registration Dossier
Registration Dossier
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EC number: 202-431-1 | CAS number: 95-55-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Code of Fed Reg 16, Sec 1500.41
- Principles of method if other than guideline:
- 24h exposure
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-aminophenol
- EC Number:
- 202-431-1
- EC Name:
- 2-aminophenol
- Cas Number:
- 95-55-6
- Molecular formula:
- C6H7NO
- IUPAC Name:
- 2-aminophenol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- none
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no information
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: one set of animals only shaved, others shaved and abraded
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- 24h
- Observation period:
- 72h
- Number of animals:
- 6
- Details on study design:
- The left side of the back was shaved (intact skin) and the right side was shaved and scarifed.
Scoring was done after 24 and 72 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72h
- Score:
- 0.7
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.83
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72h
- Remarks:
- intact and scarified skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72h
- Remarks:
- mean of 0.66 for scarified skin
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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