Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
review article or handbook
Title:
Pharmacology and toxicology of the rare earth elements
Author:
Haley T.J.
Year:
1965
Bibliographic source:
Journal of pharmaceutical sciences

Materials and methods

Principles of method if other than guideline:
The acute lethal doses of the cerium compounds, as published in diverse scientific publications, have been reviewed.

Test material

Constituent 1
Chemical structure
Reference substance name:
Cerium
EC Number:
231-154-9
EC Name:
Cerium
Cas Number:
7440-45-1
Molecular formula:
Ce
IUPAC Name:
cerium(3+)
Details on test material:
Cerium compounds: cerium chloride, cerium citrate chloride, cerium nitrate

Test animals

Species:
other: frog, mouse, rat, guinea pig

Administration / exposure

Route of administration:
other: subcutaneous, intraperitoneal, intravenous, oral

Results and discussion

Any other information on results incl. tables

This review collects the LD50 values of cerium compounds as applied to diversed animal species:

Chemical

Species, sex

LD50 (mg/Kg)

Administration

Reference

Cerium chloride

Frog

About 300

Subcutaneous

Hara S, Arch. Expil. Pathol Pharmakol 100, 230 (1923)

 

Mouse

5.000 – 10.000

subcutaneous

Ibid, 100, 217 (1923)

 

Mouse

296 – 420

intraperitoneal

Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)

 

Rat

2.000 – 4.000

subcutaneous

Ibid, 100, 217 (1923)

 

Rat

50– 60

intravenous

Maxwll LC, Bischoff F, J. Pharmacol. Expil Therap. 43, 61 (1931)

 

Guinea pig

40 – 77

Intraperitoneal

Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)

Cerium citrate chloride

Rat

128 – 167

Intraperitoneal

Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)

 

Guinea pig

73 – 146

Intraperitoneal

Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)

Cerium nitrat

Mouse, female

435 – 508

Intraperitoneal

Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)

 

Rat, female

238 – 354

Intraperitoneal

Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)

 

Rat, female

3.684 – 4.788

oral

Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)

 

Rat, female

3,4 - 5,6

intravenous

Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)

 

Rat, male

32,8 – 74,4

intravenous

Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)

Applicant's summary and conclusion