Cerium

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Adequacy of study:

other information

Reliability:

4 (not assignable)

Data source

Reference

Reference Type:

review article or handbook

Title:

Pharmacology and toxicology of the rare earth elements

Author:

Haley T.J.

Year:

1965

Bibliographic source:

Journal of pharmaceutical sciences

Materials and methods

Principles of method if other than guideline:

The acute lethal doses of the cerium compounds, as published in diverse scientific publications, have been reviewed.

Test material

Test material information

Constituent 1

Reference substance name:

Cerium

EC Number:

231-154-9

EC Name:

Cerium

Cas Number:

7440-45-1

Molecular formula:

Ce

IUPAC Name:

cerium(3+)

Details on test material:

Cerium compounds: cerium chloride, cerium citrate chloride, cerium nitrate

Test animals

Species:

other: frog, mouse, rat, guinea pig

Administration / exposure

Route of administration:

other: subcutaneous, intraperitoneal, intravenous, oral

Results and discussion

Any other information on results incl. tables

This review collects the LD50 values of cerium compounds as applied to diversed animal species:

Chemical	Species, sex	LD50 (mg/Kg)	Administration	Reference
Cerium chloride	Frog	About 300	Subcutaneous	Hara S, Arch. Expil. Pathol Pharmakol 100, 230 (1923)
	Mouse	5.000 – 10.000	subcutaneous	Ibid, 100, 217 (1923)
	Mouse	296 – 420	intraperitoneal	Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)
	Rat	2.000 – 4.000	subcutaneous	Ibid, 100, 217 (1923)
	Rat	50– 60	intravenous	Maxwll LC, Bischoff F, J. Pharmacol. Expil Therap. 43, 61 (1931)
	Guinea pig	40 – 77	Intraperitoneal	Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)
Cerium citrate chloride	Rat	128 – 167	Intraperitoneal	Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)
	Guinea pig	73 – 146	Intraperitoneal	Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957)
Cerium nitrat	Mouse, female	435 – 508	Intraperitoneal	Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)
	Rat, female	238 – 354	Intraperitoneal	Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)
	Rat, female	3.684 – 4.788	oral	Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)
	Rat, female	3,4 - 5,6	intravenous	Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)
	Rat, male	32,8 – 74,4	intravenous	Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963)