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EC number: 212-112-9 | CAS number: 763-69-9
The test compound did not produce adverse clinical signs, changes in the feed consumption, hematological determinations, and organ weights, or morphological changes in organs and tissues. Mortality was observed on Day 3 in two animals that received the test material intratracheal. The test compound produces no mortality when administered into the gastrointestinal tract. The two animals that replaced the animals that died, though of a comparable weight when placed on the study, lost weight overnight. Their loss of weight caused the mean body weight of the high-dose group to be significantly lowered on Day 4. The lost weight was subsequently regained. With the exception of this incident, the body weights of all test animals were comparable to the controls throughout the study. At 1000 mglkg, the aspartate aminotransferase and creatinine levels were slightly increased in both sexes, the sorbitol dehydrogenase levels were moderately increased in the males and slightly increased in the females, and the alanine aminotransferase levels were slightly increased in the females. The clinical chemistry determinations of the 100 mg/kg males were comparable to the controls. The probable site of toxic action is the liver. The no observed adverse effect level (NOAEL) for Ethyl 3-Ethoxypropionate is 1000 mg/kg bw/day based on slight changes in liver enzymes. The no observed effect level is 100 mg/kg bw/day.
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