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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Description of key information

Valid experimental GLP-study according to EU testing guideline A.8 (HPLC method).
General Physical Chemistry, Schering AG, Berlin. Study report No. A01517(APC 61/00), author M. Brehm, dated  2000-08-02.
Result: log Pow = 2.0       (95% confidence limits 1.8 to 2.3)

Key value for chemical safety assessment

Log Kow (Log Pow):
2
at the temperature of:
25 °C

Additional information

Valid experimental GLP-study according to EU testing guideline A.8 (HPLC method).

General Physical Chemistry, Schering AG,. Study report No. A01517(APC 61/00), author M. Brehm, dated 2000-08-02.

Result: log Pow = 2.0      (95% confidence limits 1.8 to 2.3)

 

 

The n-octanol/water partition coefficient of hydrocortisone-21-acetate was determined at 25°C according to EU testing method A.8, following OECD Testing Guideline 117 (HPLC method) to be (at 25°C, pH7):

                                log Pow= 2.0     (95 % confidence limits 1.8 to 2.3)

This method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.