Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
Intravenous
Type of information:
other: online database
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Data obtained from an authoritative secondary source.

Data source

Reference
Reference Type:
other: online database
Title:
ChemIDplus database: 2-hydroxymethylpyridine
Year:
2017
Bibliographic source:
https://chem.nlm.nih.gov/chemidplus/rn/586-98-1

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data cited in ChemIDplus database. Only result is provided on the database.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-pyridylmethanol
EC Number:
209-592-7
EC Name:
2-pyridylmethanol
Cas Number:
586-98-1
Molecular formula:
C6H7NO
IUPAC Name:
2-pyridylmethanol
Test material form:
liquid
Details on test material:
- State: Liquid
- Color: Clear light yellow to orange liquid.
- Moisture content (by KF method): 0.50% (max)

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No other information provided in the data source.

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Details on exposure:
No other information provided in the data source.
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No other information provided in the data source.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 000 mg/kg bw
Based on:
not specified
Mortality:
No data
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No other information provided in the data source.

Applicant's summary and conclusion

Conclusions:
The LD50 of mouse is found to be 1000 mg/kg bw through intravenous route of administration of 2-hydroxymethylpyridine.
Executive summary:

The LD50 of mouse is found to be 1000 mg/kg bw through intravenous route of administration of 2-hydroxymethylpyridine.