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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study was performed according to OECD 401 but before GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
no GLP implemented at that time
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chlorooctane
EC Number:
203-915-5
EC Name:
1-chlorooctane
Cas Number:
111-85-3
Molecular formula:
C8H17Cl
IUPAC Name:
1-chlorooctane

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, Fuellinsdorf, Switzerland
- Age at study initiation: 6-8 weeks
- Weight at study initiation: males 155-262g, females 155-201g
- Fasting period before study: overnight
- Housing: 5 per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 week


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12


IN-LIFE DATES: From: 31. August To: 17. December

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Details on oral exposure:
VEHICLE
- Amount of vehicle (if gavage): 10 mL at 500, 3000 and 10000 mg/kg bw; 20 mL at 5000 and 20000 mg/kg bw
Doses:
500, 3000, 5000, 10000 and 20000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing at the day of administration and days 7 and 14 thereafter, observations at several time points on the day of administration and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
The LOGIT model could not be applied to the observed rates of death. The LD50 was estimated without use of a statistical model.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 20 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occured in dose groups 500, 3000, 5000 and 10000 mg/kg bw.
Dose group 20000 mg/kg bw 1 of 5 females died on day 4
Clinical signs:
other: The main symptoms observed were sedation, dyspnoea, curved or ventral body position, diarrhoea, ruffled fur.
Gross pathology:
No pathological organ changes were seen in all test animals.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
Under the present conditions, a single oral administration by gavage revealed a LD50 of greater than 20000 mg/kg bw. Clinical symptoms observed were sedation, dyspnoea, curved or ventral body position, diarrhoea and ruffled fur. No pathological findings were observed in all animals.