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EC number: 203-233-8
CAS number: 104-75-6
Based on the pH-corrected log Koc and the ready biodegradability of the substance significant long-term adsorption to solid soil phase is not expected.
In accordance with column 2 of REACH Annexes
VIII and IX, the study does not need to be conducted if based on the
physicochemical properties the substance can be expected to have a low
potential for adsorption (e.g. the substance has a low octanol water
partition coefficient), or the substance and its relevant degradation
products decompose rapidly. 2-ethylhexylamine has a low log Kow (log Kow
= 2.82; measured, Sangster, 1987) and is readily biodegradable in
by the MCI method and the log-Kow method of KOCWIN v2.00 (EPISuite
v4.11; BASF SE 2015) calculated for 2-ethylhexylamine log Koc values of
2.65 (MCI) and 2.46 (log Kow).
a pKa value of 10.41 indicates that the molecule will primarily exist as
a cation in the environment. Cations generally adsorb stronger to soils
containing organic carbon and clay than their neutral counterparts.
Therefore, the KOCWIN-model may underestimate adsorption to organic
carbon, as it does not consider the ionic structure of the molecule. In
a calculation conducted according Franco & Trapp (2008, 2009 & 2010), a
pH-corrected log Koc value of 3.91 (at pH 7) was calculated.
referring to the charged molecule at pH 7, the substance is expected to
adsorb to suspended solids and sediment. However, considering the ready
biodegradability of the substance significant long-term adsorption to
the solid soil phase is not expected.
13 of Regulation (EC) No 1907/2006, it is laid down that information on
intrinsic properties of substances may be generated by means other than
tests, provided that the conditions set out in Annex XI (of the same
Regulation) are met. Furthermore according to Article 25 of the same
Regulation testing on vertebrate animals shall be undertaken only as a
Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if
(1) the scientific validity of the (Q)SAR model has been established,
(2) the substance falls within the applicability domain of the (Q)SAR
model, (3) the results are adequate for the purpose of classification
and labeling and/or risk assessment and (4) adequate and reliable
documentation of the applied method is provided.
assessment of 2-ethylhexylamine (Q)SAR
results were used for the estimation of the adsorption potential. The
criteria listed in Annex XI of Regulation (EC) No 1907/2006 are
considered to be adequately fulfilled and therefore the endpoint(s)
sufficiently covered and suitable for risk assessment.
further experimental studies on the adsorption potential are not
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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