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EC number: 203-233-8 | CAS number: 104-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute Toxicity:
- oral: LD50 = 316 mg/kg bw (male/female rat) equivalent to OECD 401;
- inhalation: LC50 < 1.548 mg/L air (male/female rat) according to OECD 403;
- dermal: study using 'rabbit' as test species - disregarded
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 316 mg/kg bw
- Quality of whole database:
- Well documented study which is similar to Guideline and sufficient for assessment.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 1 548 mg/m³
- Quality of whole database:
- Guideline study with acceptable restrictions performed under GLP conditions.
Acute toxicity: via dermal route
Endpoint conclusion
- Quality of whole database:
- Only data from secondary sources are available.
Additional information
Oral:
In a study which was in large parts equivalent to methods described in OECD guideline 401, the LD50 for oral acute toxicity in rats was calculated as ca. 316 mg/kg body weight. Doses of 158, 316, 632 and 1264 mg/kg bw of an aqueous solution were applied by gavage followed by a post dose observation period of 7 days. Main clinical signs observed were strongly elevated respiration, anancasm to chew, salivation, strong twitches, dyspnoea, salivation, salaam convulsions, tremor, extension convulsions. At necropsy, kidney obstructions, red-pink coloring of the stomach were noted (BASF AG, 1968; reliability score: 2). Another study is reporting an LD50 of 446 mg/kg bodyweight with occurring lung hemorrhage and severe congestion of visceral organs (Smyth 1949; reliability score: 2).
Inhalation:
Acute inhalation toxicity was analyzed according to OECD guideline 403 but with only 1 concentration tested (Hoechst AG 1988, reliability score: 2). At a concentration of 1.548 mg/L air all rats died within 40 - 177 minutes after the start of exposure. Exposed animals showed impairment of respiration, salivation, nasal discharge and periodically arising tonic spasms. At necropsy, macroscopic dark red spots were found on the lungs, and when the lungs were opened small quantities of white foam were detected.
Additional data were available from an inhalation risk test (IRT) which meets generally accepted scientific principles (BASF AG, 1968; reliability score 2). The inhalation of a saturated vapor-air mixture for 30 min caused mortality. Clinical signs were escape attempts, mucosal irritation of the upper tract, elevated respiration, blood crusted snouts and eyes, tremor, unsteady gait, abdominal-lateral position, chemical burns of the corneal. At necropsy, chronic bronchitis, questionable coloring of blood and lungs were observed (BASF AG, 1968; reliability score: 2). In a further IRT with limited data provided, substantially saturated vapors produced at room temperature were lethal to rats in 2 hours but 6 of 6 survived a 1-hour exposure (Smyth 1949; reliability score: 2).
Dermal:
An acute dermal toxicity study does not need to be conducted as the test item is considered to be highly corrosive to skin (Skin Corrosion Category 1A, H314).
From a secondary source publication a dermal LD50 of 600 mg/kg bw was reported (RTECS entry 1978; reliability score: 4). A more recent specification in RTECS says 600 µL/kg bw = 474 mg/kg bw. However, this study was conducted using 'rabbit' as test species. The rabbit is the preferable laboratory animal for testing dermal corrosivity (highly sensitive in terms of corrosive effects). But the highly sensitive rabbit is not the appropriate species for acute dermal toxicity testing using corrosive substances. In the RTECS entry no details on methodology, study design, exposure duration etc. are given. In the dermal corrosivity study necrosis was observed within 30 min post exposure (exposure duration 3 min). Thus, it is unclear if death of rabbits was due to systemic toxicity of the test substance following dermal administration, or due to a stress response to the severe local effects (destroyed skin tissue as corrosion response), and in addition, if damage of the skin facilitated increased systemic absorption/exposure to the substance. Further, 2-Ethylhexylamine is classified as acute toxic via the oral route category 4. A retrospective analysis of data from acute oral and dermal toxicity testing, performed on pesticide active substances and new chemical entities submitted for the Notification of New Substances Regulations (a total of 240 substances), has demonstrated that there is a relationship between dermal acute toxicity and oral acute toxicity, and there are no significant numbers of compounds that are classified as a potential hazard only via the dermal route (Creton et al. 2010: Acute toxicity testing of chemicals - Opportunities to avoid redundant testing and use alternative approaches. Critical Reviews in Toxicology; 40(1), 50-83).
In conclusion, because the existing piece of information is not assignable and the available data a derived from an inappropriate test species 2-Ethylhexylamine will not be classified for acute dermal toxicity.Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. The substance is considered to be classified as Cat. 4 for acute oral toxicity (H302) and as Cat. 2 (H330) for acute inhalative toxicity under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EC) No 2017/776.
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