2-ethylhexylamine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexylamine

EC Number:

203-233-8

EC Name:

2-ethylhexylamine

Cas Number:

104-75-6

Molecular formula:

C8H19N

IUPAC Name:

2-ethylhexylamine

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gassner
- Weight at study initiation: 130-200 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 2.0, 4.0 8.0 and 20 % aqueous solution containing Traganth

Doses:

200, 400, 800, 1600 µl/kg bw = 158, 316, 632 and 1264 mg/kg bw; conversion into mg/kg is based on the density d= 0.79g/cm3 according to BASF internal data

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of application and daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

316 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 400 cm³/kg bw; calculated with a density of 0.79 g/cm³

Mortality:

1264 mg/kg bw dosing group: 20/20 within 1 hour
632 mg/kg bw dosing group: 20/20 within 1 hour
316 mg/kg bw dosing group: 10/20 within 1 hour
158 mg/kg bw dosing group: 0/20

Clinical signs:

200 cm³/kg bw dosing group:
strongly elevated respiration, anancasm to chew, slight salivation, slight tremor (females), fitful breathing on day 1, free of symptoms on day 2

400-800 cm³/kg bw dosing group:
strong anancasm to roll, strong twitches, dyspnoea, salivation, on day 3 without findings

1600 cm³/kg bw dosing group:
salaam convulsions, Tremor, extension convulsions, salivation, foreleg movements

Body weight:

no data

Gross pathology:

Died animals: Kidney obstructions, red-pink coloring of the stomach
Sacrificed animals: without findings

Any other information on results incl. tables

The test substance caused systemic toxicity (including mortality) in a dose dependent manner.

Mortality

Dose (µL (kg)	Conc. (%)	No. of animals	died within  1 hour 24 hours 48 hours 7 days
1600	20	20	20/20	20/20	20/20	20/20
800	8	20	20/20	20/20	20/20	20/20
400	4	20	10/20	10/20	10/20	10/20
200	2	20	0/20	0/20	0/20	0/20

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria