Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1972
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to a scientifically acceptable protocol, however no analytical verification of exposure concentration was carried out.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane
EC Number:
222-217-1
EC Name:
2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane
Cas Number:
3388-04-3
Molecular formula:
C11H22O4Si
IUPAC Name:
trimethoxy[2-(7-oxabicyclo[4.1.0]hept-3-yl)ethyl]silane
Details on test material:
- Physical state: clear liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Concentrated vapour was generated at a temperature of approximately 22C, by passing dried air at the rate of 2.5 litres per minute through a fritted glass disc immersed to a depth of at least one inch in 50 ml of test material. The exposure chamber was 9 litres.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
'concentrated vapour'
No. of animals per sex per dose:
six females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Exp. duration:
8 h
Remarks on result:
other: NO LC50 established. No analytical verification of exposure concentration conducted.
Mortality:
There were no mortalities.
Clinical signs:
other: The animals appeared to be normal upon removal from the chamber.
Body weight:
5/6 animals gained weight normally during the 14 day observation period.
Gross pathology:
60% lung consolidation was observed in the rat lost weight. The study authors attributed this pathology to a presumed pre-existing extraneous infection, which was considered not related to inhalation of the test material.

Any other information on results incl. tables

Exposure to concentrated vapours at room temperature for eight hours killed none of six animals. The substance is described as having 'slight hazard' via inhalation exposure.

Applicant's summary and conclusion

Interpretation of results:
other: data not sufficient for classification purposes
Remarks:
Criteria used for interpretation of results: not specified
Conclusions:
No deaths are reported in a summary report in response to an 8 hour exposure to concentrated vapours of the test material.