Registration Dossier
Registration Dossier
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EC number: 222-217-1 | CAS number: 3388-04-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a scientifically acceptable protocol, however no analytical verification of exposure concentration was carried out.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane
- EC Number:
- 222-217-1
- EC Name:
- 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane
- Cas Number:
- 3388-04-3
- Molecular formula:
- C11H22O4Si
- IUPAC Name:
- trimethoxy[2-(7-oxabicyclo[4.1.0]hept-3-yl)ethyl]silane
- Details on test material:
- - Physical state: clear liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Concentrated vapour was generated at a temperature of approximately 22C, by passing dried air at the rate of 2.5 litres per minute through a fritted glass disc immersed to a depth of at least one inch in 50 ml of test material. The exposure chamber was 9 litres.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- 'concentrated vapour'
- No. of animals per sex per dose:
- six females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Exp. duration:
- 8 h
- Remarks on result:
- other: NO LC50 established. No analytical verification of exposure concentration conducted.
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: The animals appeared to be normal upon removal from the chamber.
- Body weight:
- 5/6 animals gained weight normally during the 14 day observation period.
- Gross pathology:
- 60% lung consolidation was observed in the rat lost weight. The study authors attributed this pathology to a presumed pre-existing extraneous infection, which was considered not related to inhalation of the test material.
Any other information on results incl. tables
Exposure to concentrated vapours at room temperature for eight hours killed none of six animals. The substance is described as having 'slight hazard' via inhalation exposure.
Applicant's summary and conclusion
- Interpretation of results:
- other: data not sufficient for classification purposes
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- No deaths are reported in a summary report in response to an 8 hour exposure to concentrated vapours of the test material.
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