Registration Dossier
Registration Dossier
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EC number: 202-430-6 | CAS number: 95-54-5
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Cohort mortality study of retired fur dyers and dressers.
- Author:
- Haring, M., Walrath, J. and Waxweiler, R.
- Year:
- 1 982
- Bibliographic source:
- Am. J. Epidemiol., 116(3):570.
Materials and methods
Test material
- Reference substance name:
- o-phenylenediamine
- EC Number:
- 202-430-6
- EC Name:
- o-phenylenediamine
- Cas Number:
- 95-54-5
- Molecular formula:
- C6H8N2
- IUPAC Name:
- benzene-1,2-diamine
Constituent 1
Results and discussion
- Results:
- A cohort of 1018 fur dyers and dressers pensioned between 1952 and 1977 was identified. Death certificates were obtained for 97.7% of the 540 deaths. Comparisons with the population revealed significantly higher SMRs for all malignant neoplasms combined among all fur workers. Dyers experienced elevated mortality from stomach cancer. Dressers had a three-fold increase in deaths from lung cancer. Fur dyers had exposure to oxidative dye components including toluenediamine and phenylenediamine. Dressers have limited dye exposure and are mainly exposed to tanning chemicals and wood dust.
Applicant's summary and conclusion
- Conclusions:
- Comparisons with the population revealed significantly higher SMRs for all malignant neoplasms combined among all fur workers. Dyers experienced elevated mortality from stomach cancer. Dressers had a three-fold increase in deaths from lung cancer.
- Executive summary:
A cohort of 1018 fur dyers and dressers pensioned between 1952 and 1977 was identified. Death certificates were obtained for 97.7% of the 540 deaths. Comparisons with the population revealed significantly higher SMRs for all malignant neoplasms combined among all fur workers. Dyers experienced elevated mortality from stomach cancer. Dressers had a three-fold increase in deaths from lung cancer. Fur dyers had exposure to oxidative dye components including toluenediamine and phenylenediamine. Dressers have limited dye exposure and are mainly exposed to tanning chemicals and wood dust.
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