Registration Dossier
Registration Dossier
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EC number: 202-430-6 | CAS number: 95-54-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Regioselective N-acetylation as a route of nitro-p-phenylenediamine metabolism by rat liver cytosol.
- Author:
- Nakao, M., Goto, Y., Matsuki, Y., Hiratsuka, A., and Watabe, T.
- Year:
- 1 990
- Bibliographic source:
- Chem. Pharm. Bull., 38(9):2561-2566.
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Regioselectivity in N-acetylation of nitro-p-phenylenediamine, a widely used hair dye component, by rat liver cytosolic N-acetyltransferases was studied in relation to its substituent effects on enzymatic N-acetylation of mono-substituted anilines. The steric hindrance effect of the nitro group on the cytosolic N-acetylation of the ortho amino group was revealed by a comparative study carried out by using aniline, three respective regioisomers of nitroanilines and phenylenediamines as model substrates.
Test material
- Reference substance name:
- o-phenylenediamine
- EC Number:
- 202-430-6
- EC Name:
- o-phenylenediamine
- Cas Number:
- 95-54-5
- Molecular formula:
- C6H8N2
- IUPAC Name:
- benzene-1,2-diamine
Constituent 1
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- o-phenylenediamine N-monoacetate
Applicant's summary and conclusion
- Conclusions:
- Enzymatic N-acetylation of o-phenylenediamine by rat liver cytosol resulted in the formation of a completely stable product which underwent no further metabolism during a 60 minute incubation period.
- Executive summary:
Enzymatic N-acetylation of o-phenylenediamine by rat liver cytosol resulted in the formation of a completely stable product which underwent no further metabolism during a 60 minute incubation period.
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