Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Secondary source reviewed, original document not reviewed.

Data source

Reference
Reference Type:
secondary source
Title:
Development of a flow cytometric method for mutagenicity testing in mouse germ cells.
Author:
Otto, F. J. and H. Oldiges
Year:
1986
Bibliographic source:
Wissenschaft und Umwelt, 1:15-30 (cited in ACGIH (2001). Documentation of TLVs).

Materials and methods

Test guideline
Guideline:
other: guideline not reported
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-phenylenediamine
EC Number:
202-430-6
EC Name:
o-phenylenediamine
Cas Number:
95-54-5
Molecular formula:
C6H8N2
IUPAC Name:
benzene-1,2-diamine

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Doses / concentrationsopen allclose all
Dose / conc.:
200 other: mg/kg
Dose / conc.:
400 other: mg/kg

Results and discussion

Observed effects

o-Phenylenediamine increased the portion of diploid sperm in mice that were treated intraperitoneally with 200 or 400 mg/kg.

Applicant's summary and conclusion

Conclusions:
o-Phenylenediamine increased the portion of diploid sperm in mice that were treated intraperitoneally with 200 or 400 mg/kg.
Executive summary:

o-Phenylenediamine increased the portion of diploid sperm in mice that were treated intraperitoneally with 200 or 400 mg/kg.