Registration Dossier
Registration Dossier
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EC number: 219-588-7 | CAS number: 2469-55-8
Endpoint summary
Administrative data
Description of key information
According to Section 8.5 of Annex VII, an acute oral toxicity study with the registered substance is not required as the substance is classified as corrosive to the skin.
In the key acute dermal toxicity study conducted according to a protocol similar to OECD 402 and in compliance with GLP, the LD50 value reported for 3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine was ≥2000 mg/kg bw (IRDC, 1985).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
According to Section 8.5 of Annex VII, an acute oral toxicity study with the registered substance is not required as the substance is classified as corrosive to the skin.
In the supporting acute oral toxicity study, conducted according to a protocol similar to OECD 423 and in compliance with GLP, the reported LD50 value for 3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine was concluded by the study authors to be <500 mg/kg bw (IRDC, 1985). The reviewers consider that the result should be considered as an LDL0 value.
Following single oral gavage administration of 500 or 5000 mg/kg bw undiluted test substance to two male rats per group, mortality was observed at all dose levels. Both animals treated with 500 mg/kg bw died on day 2 post-administration, while both animals treated with 5000 mg/kg bw died within 4 hours after dosing.
In the key acute dermal toxicity study conducted according to a protocol similar to OECD 402 and in compliance with GLP, the LD50 value reported for 3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine was ≥2000 mg/kg bw (IRDC, 1985).
Following single dermal 24-hour application of 200 or 2000 mg/kg bw of undiluted test material onto the skin of one male and one female rabbit per group, no mortality was observed during the study period. No clinical signs, body weight changes or port-morterm examinations were reported.
Justification for classification or non-classification
Based on the available data for 3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine, no classification for acute toxicity is required according to Regulation (EC) No. 1272/2008. The substance is classified as corrosive (see Section 7.3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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