Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 931-275-3 | CAS number: 1125503-33-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint conclusion:
- adverse effect observed (corrosive)
- Endpoint conclusion:
- no study available
To assess the irritancy potential of Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS) to the skin an acute dermal irritation/corrosion toxicity study was performed in the New Zealand White rabbit. Based on the resultsof this study the test substance is regarded as corrosive. In accordance with column 2 of Reach Regulation (EC) No 1907/2006 Annex VIII the in-vivo eye irritation study as well as the acute inhalation toxicity study (required in section 8.2.1 and 8.5, respectively) does not need to be conducted as the test substance is corrosive to the skin.
To assess the irritancy potential of Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS) to the skin an acute dermal irritation/corrosion toxicity study was performed in the New Zealand White rabbit.
A single 4-hour, semi-occluded application of the test material to the intact skin of three rabbits produced well-defined erythema, extending beyond the treatment site, very slight or slight oedema. Additional dermal reactions noted 7 or 14 days after treatment included hard, light brown coloured scabs, hyperkeratinisation, dried blood, loss of skin elasticity, glossy skin and reduced fur re-growth. Scar tissue indicative of corrosion was also noted at one treated skin site on day 14.
An additional 3-minute semi-occluded application was performed on another group of three animals to assess the appropriate risk phrase. Very slight erythema was confined to two treated skin sites one hour after patch removal. No other adverse skin reactions were noted. The test material was regarded as corrosive according to EC labeling regulations.
As the test substance is corrosive to the skin it is assumed that the substance is also corrosive to the eye and no test was performed on animal welfare reasons.With regard to inhalation toxicity of the test item no animal study was performed. This is well-founded as inhalation is no endpoint of concern and since inhalation is no critical route of exposure and no peak exposures are to be expected.
Effects on skin irritation/corrosion: corrosive
Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS) was found to be corrosive to rabbit skin according to EEC labelling regulations (Directive 67/548/EEC) and requires the symbol “C” and risk phrase R 34 „CAUSES BURNS”.
According to theRegulation (EC) No 1272/2008 of the European Parliament and of the Council, 16 December 2008 (CLP or GHS (Global Harmonized System for classification, labeling and packaging) Annex 1, Chapter 3.2.2.6.3 the test substance has to be classified: "Skin Corr. Cat 1C (exposition > 1 hour ≤ 4 hours; observation time ≤14 days), H314".
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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