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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 February 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Only a 1 page study summary, though the critical information for this endpoint is included.
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
not specified
GLP compliance:
yes
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
Laser scattering/diffraction
Type of particle tested:
other: no data
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 2017/02
- Expiration date of the lot/batch: No data
- Purity test date: No data

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
- Stability under test conditions: No data
- Solubility and stability of the test substance in the solvent/vehicle: No data
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No data

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: No data
- Final dilution of a dissolved solid, stock liquid or gel: No data
- Final preparation of a solid: No data
Percentile:
D10
Mean:
17 µm
Remarks on result:
other: average of three measurements
Percentile:
D50
Mean:
72 µm
Remarks on result:
other: average of three measurements
Percentile:
D90
Mean:
151 µm
Remarks on result:
other: average of three measurements
Conclusions:
In a particle size distribution study with tetraammineplatinum(II) hydrogen carbonate, respective d10, d50 and d90 values of 17, 72 and 151 μm were measured.
Executive summary:

In a guideline (ISO 13320) particle size distribution study with tetraammineplatinum(II) hydrogen carbonate, respective d10, d50 and d90 values of 17, 72 and 151 μm were measured using laser diffraction.

Description of key information

In a guideline (ISO 13320) particle size distribution study with tetraammineplatinum(II) hydrogen carbonate, respective d10, d50 and d90 values of 17, 72 and 151 μm were measured using laser diffraction (Mekelburger, 2017b)

Additional information