Cinnamyl propionate

Endpoint summary

Description of key information

Biodegradation in water:

Biodegradability of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate(CAS No.103-56-0) is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. Percent Biodegradation of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate estimated was ------- % by using BOD parameter and microorganisms as inoculum in 28 days. By this value of percent biodegradation it is concluded that test chemical (2E)-3-phenylprop-2-en-1-yl propanoate is readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound (2E)-3-phenylprop-2-en-1-yl propanoate(CAS No.103 -56 -0). If released in to the environment, 24.9 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate in sediment is estimated to be135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.668 %), indicates that test chemical (2E)-3-phenylprop-2-en-1-yl propanoate is not persistent in sediment.

 

Biodegradation in soil:

The half-life period of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate (CAS No.103-56-0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.3 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals islow .

Additional information

Biodegradation in water:

Predicted data for the target compound (2E)-3-phenylprop-2-en-1-ylpropanoate (CAS No.103-56-0) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which is summarized as below:

Biodegradability of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate(CAS No.103-56-0) was predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. Percent Biodegradation of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate estimated was 89.16 % by using BOD parameter and microorganisms as inoculum in 28 days. By this value of percent biodegradation it is concluded that test chemical (2E)-3-phenylprop-2-en-1-yl propanoate is readily biodegradable.

Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to predict the biodegradation potential of the test compound(2E)-3-phenylprop-2-en-1-yl propanoate (CAS no.103-56-0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical (2E)-3-phenylprop-2-en-1-yl propanoateis expected to be readily biodegradable.

In a supporting weight of evidence study from authoritative database (J check, 2017) the Biodegradation experiment was carried out of read across chemical 2-dimethyaminoethyl methacrylat (CAS no. 2495-37-6) by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are O2 consumption (BOD), and test material analysis by HPLC .The initial concentration of read cross chemical was 100 mg/L and equipments used in study was of standard type. Read across chemical showed 81% degradation by O2 consumption parameter and 100% degradation by test material analysis parameter using HPLC. Therefore it is concluded that read across chemical 2-dimethyaminoethyl methacrylat is readily biodegradable.

In another supporting weight of evidence study of read across chemical (2E)-3-phenylprop-2-enoic acid (CAS no. 621-82-9)from Applied and Environmental Microbiology Journal (1979) the experiment was carried out to test the biodegradability of read across chemical (2E)-3-phenylprop-2-enoic acid (CAS no. 621-82-9) in serum bottles in anaerobic conditions at 35 oC temperature in dark. The pre-reduced defined medium was used in serum bottles with 1% v/v vitamin solution then it is inoculated10 % vol/vol seed from laboratory anaerobic digester fed primary settled sewage sludge on 15 day detention time. The anaerobic condition was attained by removing Oxygen from the medium by boiling, followed by the addition of the sodium sulfide reducing agent then Serum bottles (250-ml) were flushed (500 ml/min) with oxygen-free gas for 20 min before the inoculated medium was added. Sampling was done by using A 1-ml gas-tight glass syringe. The volume of gas produced by 250-ml serum-bottle cultures was measured daily by displacement of plunger lubricated with water in 20 mL glass syringe fitted with a 20 guage needle. The volume of gas (Methane and carbon dioxide) produced was equal to amount of degradation of substrate. The volume of gas produced by 250-ml serum-bottle cultures was measured daily by displacement of plunger lubricated with water in 20 mL glass syringe fitted with a 20 guage needle and Substrate concentration was determined by diluting a centrifuged sample and assaying it in a spectrophotometer at a known characteristic ultraviolet wavelength. After 28 days of incubation 87% biodegradability was observed of read cross chemical (2E)-3-phenylprop-2-enoic acid. So it is concluded that the chemical is readily biodegradable in anaerobic conditions.

 

On the basis of above results for target chemical (2E)-3-phenylprop-2-en-1-ylpropanoate (CAS No.103-56-0) (from OECD QSAR tool box and EPI suite, 2017) and for its read across substance (from authoritative database and Applied and Environmental Microbiology Journal ), it can be concluded that the test substance (2E)-3-phenylprop-2-en-1-ylpropanoate expected to be readily biodegradable in nature.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound (2E)-3-phenylprop-2-en-1-yl propanoate (CAS No. 103-56-0). If released in to the environment, 24.9 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate in sediment is estimated to be135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.668 %), indicates that test chemical (2E)-3-phenylprop-2-en-1-yl propanoate is not persistent in sediment.

 

Biodegradation in soil:

The half-life period of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate (CAS No.103-56-0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.3 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical (2E)-3-phenylprop-2-en-1-yl propanoatein soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical (2E)-3-phenylprop-2-en-1-yl propanoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals islow .