Cinnamyl propionate

Endpoint summary

Description of key information

Acute oral toxicity

LD 50 was considered to be 3400 mg/kg, When rats were treated with Cinnamyl propionate (103-56-0) orally.

Acute dermal toxicity

The LD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate (103-56-0)by dermal application

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from peer reviewed journal

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

The acute oral toxicity of CINNAMYL PROPIONATE was performed on rats.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data available

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

No data available

Doses:

2500, 3200, 4000 and 5000 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:No data available
- Other examinations performed: clinical signs were observed

Statistics:

No data available

Preliminary study:

No data available

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 400 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed

Mortality:

At 2.56 g/kg,1/10 deaths occurred; 2/10 deaths occurred at 3.2 g/kg ,5/10 deaths occurred at 4.0 g/kg and 9/10 deaths occurred at 5.0g/kg

Clinical signs:

other: Lethargy and coma which were observed at dose levels of 4.0 and 5.0 g/kg in treated rats.

Gross pathology:

No data available

Other findings:

No data available

Interpretation of results:

other: Not classified

Conclusions:

LD 50 was considered to be 3400 mg/kg, When rats were treated with Cinnamyl propionate (103-56-0) orally.

Executive summary:

Acute oral toxicity test was performed in 10 rats at concentrations 2500, 3200, 4000 and 5000 mg/kg bw. Animals were observed for 14 days, at 2.56 g/kg,1/10 deaths occurred; 2/10 deaths occurred at 3.2 g/kg ,5/10 deaths occurred at 4.0 g/kg and 9/10 deaths occurred at 5.0g/kg. Clinical signs like lethargy and coma which were observed at dose levels of 4.0 and 5.0 g/kg. 50% mortality was calculated at dose 3400mg/kg bw. HenceLD 50 was considered to be 3400 mg/kg, When rats were treated with Cinnamyl propionate (103-56-0) orally.

 

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

3 400 mg/kg bw

Quality of whole database:

Data is Klimicsh 2 and from peer reviewed journal

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from peer reviewed journal

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

The acute dermal toxicity of CINNAMYL PROPIONATE was performed on rabbits.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data available

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

No data available

Duration of exposure:

24hr

Doses:

5000mg/kg bw

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:/no
- Other examinations performed: clinical signs were observed

Statistics:

No data available

Preliminary study:

No data available

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was not observed

Mortality:

1/10(on day 11)

Clinical signs:

other: Anorexia and diarrhea were observed in the 1 animal that died

Gross pathology:

No data available

Other findings:

No data available

Interpretation of results:

other: Not classified

Conclusions:

The LD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate (103-56-0)by dermal application

Executive summary:

Acute dermal toxicity test was performed in 10 rabbits. Test material at dose 5000mg/kg was applied under occlusion for 24hr.Observation made for 14days.1 /10 mortality observed on day 11.Clinical signs like anorexia and diarrhea were observed in the 1 animal that died. No 50% mortality was observed at dose concentration 5000mg/kg bw. Hence theLD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate(103-56-0)by dermal application

 

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Quality of whole database:

Data is Klimicsh 2 and from peer reviewed journal

Additional information

Acute oral toxicity

In different studies,Cinnamyl propionate (103-56-0),has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats forCinnamyl propionate (103-56-0),The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In experimental study given byD.L.J Opydke (Food and Cosmetics Toxicology. Vol. 12, Pg. 859, 1974).Acute oral toxicity test was performed in 10 rats at concentrations 2500, 3200, 4000 and 5000 mg/kg bw. Animals were observed for 14 days ,at 2.56 g/kg,1/10 deaths occurred; 2/10 deaths occurred at 3.2 g/kg ,5/10 deaths occurred at 4.0 g/kg and 9/10 deaths occurred at 5.0g/kg. Clinical signs like lethargy and coma which were observed at dose levels of 4.0 and 5.0 g/kg. 50% mortality was calculated at dose 3400mg/kg bw. Hence LD 50 was considered to be 3400 mg/kg, When rats were treated with Cinnamyl propionate (103-56-0) orally.

 

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for Cinnamyl propionate (103-56-0),LD50 was estimated to be 2256.20mg/kg bw, when albino Mason Wistar rats male and femalewereexposed with Cinnamyl propionate (103-56-0)orally.

Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 3600mg/kg bw on rat for Cinnamyl propionate(103-56-0)having Reliability Index: 0.87(high prediction quality)

Also it is further supported by experimental study by S.P. Bhatia a, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api(Food and Chemical Toxicology 45 (2007) S53–S57)on structurally similar read across substancecinnamyl acetate(103-54-8),In acute-oral toxicity study ,the toxic effects of cinnamyl acetate were assessed in group of 10 rats by oral route in the concentration of1460, 2220, 3330 and 5000 mg/kg/bodyweight ,Observations were made for 14 days. No deaths occurred at the 1460 mg/kg ,1/10 deaths occurred at 2220 m g/kg; 6/10 deaths at 3330 mg/kg and 10/10 at 5000 mg/kg .All deaths occurred within the first 48 h. Clinical signs observed during the study included slow respiration, lethargy, depression and coarse tremors in high doses. Therefore LD50 value is considered to be 3300mg/kg body weight when rats were exposed to cinnamyl acetate by oral route.

 Also it is further supported by experimental study given byU.S. National Library of Medicine(ChemID plus A TOXNET DATABASE.2017)on structurally similar read across substanceethyl cinnamate(103-36-6),Group of white rats were dosed per orally with a 20–45% solution of ethyl cinnamate in sunflower oil (0.2–0.5 ml/100 g bodyweight). For each species, the animals were tested 3/sex/dose and observed over a 15-day period. The fructose diphosphate aldolase in blood serum and cholinesterase levels in the blood increased. 50% mortality was observed at dose 4000mg/kg bw. Hence LD50 was considered to be 4000mg /kg bw. When white rats were treated with ethyl cinnamate (103-36-6) orally.

 

 Thus, based on the above studies and predictions onCinnamyl propionate (103-56-0)and its read across substances, it can be concluded that LD50 value is 3400mg/kg bw. Thus, comparing this value with the criteria of CLPCinnamyl propionate (103-56-0)can be “Not classified” for acute oral toxicity.

 

Acute dermal toxicity

In different studies,Cinnamyl propionate (103-56-0)has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits forCinnamyl propionate (103-56-0).The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In experimental study given by D.L.J Opydke (Food and Cosmetics Toxicology, Vol. 12, Pg. 859, 1974).Acute dermal toxicity test was performed in 10 rabbits. Test material at dose 5000mg/kg was applied under occlusion for 24hr.Observation made for 14days.1 /10 mortality observed on day 11. Clinical signs like anorexia and diarrhea were observed in the 1 animal that died. No 50% mortality was observed at dose concentration 5000mg/kg bw. Hence the LD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate(103-56-0)by dermal application

 

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for Cinnamyl propionate (103-56-0).LD50 was estimated to be 4227.69mg/kg bw.When male and female New Zealand White rabbits were exposed with Cinnamyl propionate (103-56-0) by dermal application.

 

Also it is further supported by experimental study given byD.L.J Opydke (Food and Cosmetics Toxicology. Vol. 11, Pg. 1063, 1973)on structurally similar read across substancecinnamyl acetate (103-54-8) , In acute-dermal  toxicity study , the toxic effects of cinnamyl acetate were assessed in group of 10 rabbits by dermal route.Single dermal application of neat cinnamyl acetate at a dose level of 5000 mg/kg/bodyweight which was applied for 24 h under occlusion. Observations were made over a 14-day period. No effects were observed during the study. Therefore LD50 value is considered to be >5000mg/kg body weight when rabbits were exposed to cinnamyl acetate(103-54-8) by dermal route.

 Also it is further supported by experimental study given byD.L.J Opydke (Food and Cosmetics Toxicology. Vol. 12, Pg. 721, 1974)on structurally similar read across substanceethyl cinnamate (103-36-6), In acute-dermal  toxicity study , the toxic effects of ethyl cinnamate were assessed in group of 10 rats by dermal route.Single dermal application of neat cinnamyl acetate at a dose level of 5000 mg/kg/bodyweight which was applied for 24 h under occlusion. Observations were made over a 14-day period. No effects were observed during the study. Therefore LD50 value is considered to be >5000mg/kg body weight when rats were exposed to ethyl cinnamate (103-36-6)by dermal route.

 Thus, based on the above studies and predictions onCinnamyl propionate (103-56-0)and its read across substances, it can be concluded that LD50 value is >5000 mg/kg bw. Thus, comparing this value with the criteria of CLPCinnamyl propionate (103-56-0)can be “Not classified” for acute dermal toxicity.

 

 

 

Justification for classification or non-classification

Thus, comparing this value with the criteria of CLP Cinnamyl propionate (103-56-0)can be “Not classified” for acute oral and dermal toxicity.