Cinnamyl propionate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from peer reviewed journals

Data source

Reference

Reference Type:

publication

Title:

Fragrance material review on methyl cinnamate

Author:

S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia, A.M. Api

Year:

2007

Bibliographic source:

Food and Chemical Toxicology, 45 (2007), S113–S119

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the ocular irritation potential of methyl cinnamate in rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Methyl cinnamate

EC Number:

203-093-8

EC Name:

Methyl cinnamate

Cas Number:

103-26-4

Molecular formula:

C10H10O2

IUPAC Name:

methyl (2E)-3-phenylprop-2-enoate

Test material form:

liquid

Details on test material:

Name of the test chemical: methyl (2E)-3-phenylprop-2-enoate/
Common Name: Methyl cinnamate
Moelcular Formula: C10H10O2
Molecular Weigth: 162.187 g/mol
InChI: 1S/C10H10O2/c1-12-10(11)8-7-9-5-3-2-4-6-9/h2-8H,1H3/b8-7+
Substance Type: Organic
Physical State: Liquid

Specific details on test material used for the study:

Name of the test chemical: methyl (2E)-3-phenylprop-2-enoate/
Common Name: Methyl cinnamate
Moelcular Formula: C10H10O2
Molecular Weigth: 162.187 g/mol
InChI: 1S/C10H10O2/c1-12-10(11)8-7-9-5-3-2-4-6-9/h2-8H,1H3/b8-7+
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

no data available

Test system

Vehicle:

unchanged (no vehicle)

Controls:

yes

Amount / concentration applied:

0.1 ml

Duration of treatment / exposure:

single exposure

Observation period (in vivo):

Observations were made at 1, 4, 24, 48, 72 and 96 h and daily thereafter for a total of 7 days.

Duration of post- treatment incubation (in vitro):

no data available

Number of animals or in vitro replicates:

6

Details on study design:

no data available

Results and discussion

In vitro

Other effects / acceptance of results:

no data available

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

7 d

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

Conjunctival irritation was observed in 1/6 rabbits for 24-h. methyl cinnamate was considered not irritating to eyes

Any other information on results incl. tables

Summary of the eye irritation study

Dose(%)	Vehicle	Results
100	NA	Not irritating

 

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

Conjunctival irritation was observed in 1/6 rabbits for 24-h. Under the conditions of this study,Methyl cinnamate was considered to be not irritating.

Executive summary:

The ocular irritation potential of methyl cinnamate was assessed in rabbits.0.1ml methyl cinnamate was instilled in one eye of 6 New Zealand White rabbits and observed for signs of irritation. The untreated eyes served as controls. Observations were made at 1, 4, 24, 48, 72 and 96 h and daily thereafter for a total of 7 days.Conjunctival irritation was observed in 1/6 rabbits for 24-h.Under the conditions of this study, methyl cinnamate was considered to be not irritating.