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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance material review on methyl cinnamate
Author:
S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia, A.M. Api
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45 (2007), S113–S119

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of methyl cinnamate in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl cinnamate
EC Number:
203-093-8
EC Name:
Methyl cinnamate
Cas Number:
103-26-4
Molecular formula:
C10H10O2
IUPAC Name:
methyl (2E)-3-phenylprop-2-enoate
Test material form:
liquid
Details on test material:
Name of the test chemical: methyl (2E)-3-phenylprop-2-enoate/
Common Name: Methyl cinnamate
Moelcular Formula: C10H10O2
Molecular Weigth: 162.187 g/mol
InChI: 1S/C10H10O2/c1-12-10(11)8-7-9-5-3-2-4-6-9/h2-8H,1H3/b8-7+
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: methyl (2E)-3-phenylprop-2-enoate/
Common Name: Methyl cinnamate
Moelcular Formula: C10H10O2
Molecular Weigth: 162.187 g/mol
InChI: 1S/C10H10O2/c1-12-10(11)8-7-9-5-3-2-4-6-9/h2-8H,1H3/b8-7+
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
single exposure
Observation period (in vivo):
Observations were made at 1, 4, 24, 48, 72 and 96 h and daily thereafter for a total of 7 days.
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
6
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Conjunctival irritation was observed in 1/6 rabbits for 24-h. methyl cinnamate was considered not irritating to eyes

Any other information on results incl. tables

Summary of the eye irritation study

Dose(%)

Vehicle

Results

100

NA

Not irritating

 

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Conjunctival irritation was observed in 1/6 rabbits for 24-h. Under the conditions of this study,Methyl cinnamate was considered to be not irritating.
Executive summary:

The ocular irritation potential of methyl cinnamate was assessed in rabbits.0.1ml methyl cinnamate was instilled in one eye of 6 New Zealand White rabbits and observed for signs of irritation. The untreated eyes served as controls. Observations were made at 1, 4, 24, 48, 72 and 96 h and daily thereafter for a total of 7 days.Conjunctival irritation was observed in 1/6 rabbits for 24-h.Under the conditions of this study, methyl cinnamate was considered to be not irritating.

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