Cinnamyl propionate

Endpoint summary

Description of key information

Skin sensitizing test was performed in 25 human at 4% concentration in petrolatum. The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure.After 10 days rest period , challenge application given for 48hr having same concentration as induction exposure. Evalution done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion.No sensitization was observed in any human thereforecinnamyl propionate (103-56-0) was considered to be not sensitizing in human.

 

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vivo (non-LLNA)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from peer reviewed journal

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

The skin sensitization study of cinnamyl propionate was performed on human.

GLP compliance:

not specified

Type of study:

patch test

Justification for non-LLNA method:

No data available

Specific details on test material used for the study:

Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid

Species:

other: Human

Strain:

not specified

Sex:

male

Details on test animals and environmental conditions:

No data available

Route:

epicutaneous, occlusive

Vehicle:

petrolatum

Concentration / amount:

4%

Day(s)/duration:

48hr

No.:

#1

Route:

epicutaneous, occlusive

Vehicle:

petrolatum

Concentration / amount:

4%

Day(s)/duration:

48hr

No. of animals per dose:

25

Details on study design:

Details on study design
RANGE FINDING TESTS:

MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 5
- Exposure period:48hr
- Test groups:25
- Control group:00
- Site: Forearms
- Frequency of applications: five alternate-day
- Duration:10 days
- Concentrations:4%

B. CHALLENGE EXPOSURE
- No. of exposures:1
- Day(s) of challenge:10days after last induction application
- Exposure period:48hr
- Test groups:25
- Control group:00
- Site: fresh site
- Concentrations:4%
- Evaluation (hr after challenge):24hr

Other: Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure while Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under
occlusion

Challenge controls:

No data available

Positive control substance(s):

not specified

Statistics:

No data available

Positive control results:

No data available

Reading:

1st reading

Hours after challenge:

24

Group:

test chemical

Dose level:

4%

No. with + reactions:

0

Total no. in group:

25

Clinical observations:

No skin sensitization reaction was observed

Remarks on result:

no indication of skin sensitisation

Interpretation of results:

other: not sensitizing

Conclusions:

The cinnamyl propionate (103-56-0) was considered to be as not sensitizing in human.

Executive summary:

Skin sensitizing test was performed in 25 human at 4% concentration in petrolatum.The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period, challenge application given for 48hr having same concentration as induction exposure. Evaluation done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information:

Skin sensitization 

In different studies, cinnamyl propionate (103-56-0) has been investigated for potential of skin sensitization to a greater or lesser extent. The studies are based on in vivo experiments in guinea pig and human for target chemical cinnamyl propionate (103-56-0) and its structurally similar read across substancesCinnamyl acetate(103-54-8)andEthyl cinnamate (103-36-6) the predicted data using the OECD QSAR toolbox has also been compared with the experimental data of read across.

The experimental study conducted by D.L.J. Opdyke(Food and Cosmetics Toxicology, Vol. 12, Pg. 859, 1974) to evaluate the skin sensitizing potential of cinnamyl propionate (103-56-0) in human. Skin sensitizing test was performed in 25 human at 4% concentration in petrolatum.The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period, challenge application given for 48hr having same concentration as induction exposure. Evaluation done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion.No sensitization was observed in any human therefore cinnamyl propionate (103-56-0) was considered to be not sensitizing in human.

The skin sensitization potential Cinnamyl propionate (103-56-0) was estimated by SSS (2017) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor and considering the six closest read across substances Cinnamyl propionate (103-56-0) was predicted to be not sensitizing to the skin of female Dunkin-Hartley guinea pig.

Prediction done using the Danish (Q) SAR Database, the skin sensitization was estimated to be negative on guinea pig and human for3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate. Using Battery algorithm model of Danish QSAR, Allergic Contact Dermatitis for 3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate (103-56-0) estimated to be not sensitizing when applied to human and guinea pig skin.

Supported by experimental study conducted by D.L.J. Opdyke(Food and Cosmetics Toxicology. Vol. 11, Pg. 1063, 1973) to evaluate the skin sensitizing potential of read across substance Cinnamyl acetate(103-54-8) in human. Skin sensitizing test was performed in 25 human at 5% concentration in petrolatum.The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period, challenge application given for 48hr having same concentration as induction exposure. Evaluation done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion. No sensitization was observed in any human therefore Cinnamyl acetate(103-54-8) was considered to be not sensitizing when exposed to human.

Also it is further Supported by experimental study conducted by D.L.J. Opdyke(Food and Cosmetics Toxicology. Vol. 12, Pg. 721, 1974)to evaluate the skin sensitizing potential of read across substance Ethyl cinnamate (103-36-6) in human. Skin sensitizing test was performed in 25 human at 4% concentration in petrolatum.The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period , challenge application given for 48hr having same concentration as induction exposure. Evaluation done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion. No sensitization was observed in any human therefore Ethyl cinnamate (103-36-6) was considered to be not sensitizing when exposed to human.

 

Thus based on the above predictions on cinnamyl propionate (103-56-0) as well as its read across and applying weight of evidence, it can be concluded that cinnamyl propionate (103-56-0) is not a skin sensitizer. Thus comparing the above studies with the criteria of CLP regulation, cinnamyl propionate (103-56-0) can be considered as not classified for skin sensitization.

 

 

Justification for classification or non-classification

Thus comparing the above studies with the criteria of CLP regulation, cinnamyl propionate (103-56-0) can be considered as not classified for skin sensitization.