[2-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]ethyl](2-hydroxypropyl)dimethylammonium chloride

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 08, 2015 - May 11, 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

GLP compliance:

no

Type of method:

thermal analysis

Key result

Melting / freezing pt.:

>= 185 - <= 190 °C

Individual results

Melting point / melting range (DSC measurement)

The first DSC measurement in an aluminium crucible with a hole showed an ambiguous course of the baseline. Therefore, this measurement was not used for the evaluation and the measurements were repeated in open glass crucibles to avoid an influence of the material of the crucible on the measurement.

Three DSC measurements in open glass crucibles (two up to 500°C and one up to 210°C) showed an endothermal effect in the temperature range of 165 – 230 °C with onset temperatures of 189.2 °C, 189.5 °C and 185.6 °C. The onset temperatures were derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline. The endothermal effect was followed directly by an exothermal effect (second and third measurement).

The results of the DSC measurements are summarized in Table1.

Table1: Melting point (DSC-measurements)

Ident No.	Test item [mg]	Final test temperature [°C]	Temperature range (melting) [°C]	Onset [°C]	Crucible
35028	12.40	500	Ambiguous baseline	---	Aluminium with a hole
35029	11.23	500	170 – 230	189.16	Open glass crucible
35033	10.15	500	165 – 230	189.52	Open glass crucible
35036	8.24	210	165 – 210	185.64	Open glass crucible

 

After the DSC measurement with the final test temperature of 210 °C the test item was melted. No mass loss occurred. After the DSC measurements with the final test temperature of 500 °C the crucibles contained blackened residues. Therefore, it was concluded that the test item had a melting range of 185 – 190 °C.

Conclusions:

The test item had a melting range of 185 – 190 °C.

Executive summary:

The melting point of the test item was determined in accordance with methods OECD 102 and EU A.1 (thermal analysis, DSC). The test item had a melting range of 185 – 190 °C.

Description of key information

The test item has a melting range of 185 – 190 °C under the conditions of test methods OECD 102/ EU A.1.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

185 °C