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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
reaction mass of decyl acrylate and octyl acrylate
EC Number:
911-295-9
Molecular formula:
C11H20O2 and C13H24O2
IUPAC Name:
reaction mass of decyl acrylate and octyl acrylate
Test material form:
liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg (5.7 ml/kg)
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 5 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
no mortality was observed
Clinical signs:
no data
Body weight:
no data
Gross pathology:
No sign of gross toxicity was observed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No mortality was observed after an acute exposure of 5000 mg/kg bw to 6 rats.
Executive summary:

To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance. No mortality were observed after the administration during the study, and o sign of gross toxicity were observed at the autopsy.

In conclusion, the oral LD0 of the test substance is higher than 5000 mg/kg bw.

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