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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
August / September 1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the eye irritation potential for the test substance, the right eyes of 4 animals were exposed to the test item for 24 hours. Left eye served as control. The eye's animals were examinated 24 hours and 7 days after exposure, and the score of irritation were calculated.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
reaction mass of decyl acrylate and octyl acrylate
EC Number:
911-295-9
Molecular formula:
C11H20O2 and C13H24O2
IUPAC Name:
reaction mass of decyl acrylate and octyl acrylate
Test material form:
liquid

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
no data
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
at 24 hours and day 7 after exposure.
Number of animals or in vitro replicates:
4
Details on study design:
Right eyes of animals were exposed to the test item. Left eye served as control.
Score of each effect were noted, eyes are not rinsed.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
mean
Remarks:
4 rabbits
Time point:
24 h
Score:
1
Max. score:
3
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: individual scores: 1-1-1-1
Irritation parameter:
chemosis score
Basis:
mean
Remarks:
4 rabbits
Time point:
24 h
Score:
1
Max. score:
3
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: individual scores:1-1-1-1
Irritation parameter:
iris score
Basis:
mean
Remarks:
4 rabbits
Time point:
24 h
Score:
0
Max. score:
2
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
4 rabbits
Time point:
24 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
All four animals exhibited slight conjunctival irritation, four exhibited iridial changes and two exhibited slight corneal changes at 14 hours. Except for slight discharge noted in one animal, all animals were free of ocular abnormalities by Day 7.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Test substance produced a mild reversible ocular irritation.
Executive summary:

To evaluate the eye irritatiion potential fo the test substance, the right eyes of 4 animals were exposed to the test item for 24 hours. Left eye served as control. The eye's animals were examinated 24 hours and 7 days after exposure, and the score of irritation were calculated. Slight effects were observed on the conjunctivae (redness and chemosis). These effects were reversible within 7 days. However no effect was observed on iritis and cornea. Based on the results, the test substance produced a mild reversible ocular irritation.