Registration Dossier
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EC number: 248-570-1 | CAS number: 27610-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-11-17 to 1999-11-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- STOCK AND TEST SOLUTION AND THEIR PREPARATION
- Dispersion: no
- Vehicle, solvent: no
- Concentration of vehicle/ solvent: not applicable
- Other procedures: A stock solution was prepared by mixing of 1 g/l test substance with synthetic freshwater, stirring for 18 hours and subsequently filtering.
STABILITY OF THE TEST CHEMICAL SOLUTIONS: No stability test was performed. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Strain: Daphnia magna straus; clone 5
- Source/supplier: laboratory bred
- Breeding method: The females were maintained in M4 medium in 1 l beakers. At two to three day intervals, the exuviae were siphoned off and the water was changed. In the course of this, the offspring was removed from the breeding vessels. At regular intervals of approx. 4 weeks, offspring was isolated from the vessels and served as a basis for further breeding.
- Age: not older than 24 hours
- Feeding: Scenedesmus subspicatus
- Pretreatment: Females were separated from the offspring 24 hours before the start of the test. The offspring produced overnight are transferred into the test water.
- Feeding during test: no
- Control group: 4 replicates with 5 animals each in synthetic freshwater - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- 14°dH = 250 mg CaCO3/l
- Test temperature:
- 20 +- 1 ° C
- pH:
- 7.2 - 7.9
- Dissolved oxygen:
- 90 - 104 %
- Nominal and measured concentrations:
- The measured analytical value was 76.9 mg TOC/l corresponding to 107 mg of test substance/l. This result was used for the calculatiion of test test substance.
- Details on test conditions:
- DILUTION WATER
- Source: synthetic freshwater
- Aeration: no
- Alkalinity: not mentioned
- Hardness: 14 °dH (2.5 mmol Ca2+/Mg2+)
- Salinity: CaCl2 x 2 H2O: 294 mg/l; MgSO4 x 7 H2O: 114 mg/l; NaHCO3: 65 mg/l; KCl: 6 mg/l
- TOC: not mentioned
- Ca/Mg ratio: 4:1
- Na/K ratio: 10:1
- TSS: not mentioned
- pH: 7.8
- Oxygen content: 98 %
- Conductance: not mentioned
- Holding water: synthetic freshwater
TEST SYSTEM
- Test type: static
- Concentrations: 0 (control), 2.68, 5.35, 10.7, 21.4, 42.8, 85.6 mg/l (based on TOC measurement of stock solution)
- Renewal of test solution: no
- Exposure vessel type: Round-bottom test tubes calibrated to 10 ml
- Number of replicates, individuals per replicate: 4 replicates, 5 animals per replicate
- Test temperature: 20 +/- 1 °C
- Dissolved oxygen: 90-104 %
- pH: 7.2 – 7.9
- Adjustment of pH: no
- Photoperiod: test was performed in the dark
- Intensity of irradiation: not applicable
DURATION OF THE TEST: 48 hours
TEST PARAMETER: immobilisation, pH value, dissolved oxygen
SAMPLING: after 24 and 48 hours
MONITORING OF TEST SUBSTANCE CONCENTRATION: The measured analytical value of the stock solution was 76.9 mg TOC/l corresponding - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate, 1.0 and 2.0 mg/l (historical control), 24 hours exposure
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL 22-42 mg/L
- Details on results:
- - concentration / effect data (Immobilisation)
(mg/l) 24h 48h
0 0% 0%
2.68 0% 0%
5.35 0% 5%
10.7 5% 10%
21.4 5% 20%
42.8 30% 65%
85.6 100% 100% - Results with reference substance (positive control):
- Immobilsation after 24 h: 1 mg/l: 45%; 2 mg/l: 100 %
- Validity criteria fulfilled:
- yes
- Remarks:
- not more tha 10% daphnids immobilised or trapped at the surface, dissolved oxygen at the end of the test >= 60% of air saturation, test with reference substance
- Conclusions:
- The 48h-EC50 was 31 mg/l (95% confidence interval between 22 and 42 mg/l).
- Executive summary:
In an OECD 202 -study the 48h-EC50 of 2 -butyl octanoic acid was 31 mg/l (95% confidence interval between 22 and 42 mg/l).
Reference
Description of key information
In the key study (Daphnia magna, OECD 202, GLP compliant) with 2-butyloctanoic acid the 48h-EC50 was 31 mg/l (95% confidence interval between 22 and 42 mg/l). In the ECOSAR calculation a value of 48 h-EC50 of 9.363 mg/L is predicted.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 31 mg/L
Additional information
In the key study (Daphnia magna, OECD 202, GLP compliant) with 2-butyloctanoic acid the 48h-EC50 was 31 mg/l (95% confidence interval between 22 and 42 mg/l). In the ECOSAR calculation a value of 48 h-EC50 of 3.585 mg/L is predicted.
Acute toxicity in Daphnia magna with the similar substance Reaction mass of n-undecanoic-acid and 2-methyl-decanoic-acid and 2-ethyl-nonanoic-acid and 2-propyl-octanoic-acid and 2-butyl-heptanoic-acid was tested according to OECD guideline No. 202. The study met the acceptability criteria and was conducted GLP compliant, therefore considered reliable without restrictions. The 48h-EC50 was 16 mg/L based on average exposure concentrations (95% confidence interval between 13 and 19 mg/L) and thus confirming the range of toxicity to invertebrates.
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