Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authorized database

Data source

Reference
Reference Type:
other: Authorized database
Title:
GESTIS for the CAS: 1122-62-9
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften); 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of 2-Acetylpyridine n rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
2-Acetylpyridine
Cas Number:
1122-62-9
Molecular formula:
C7H7NO
IUPAC Name:
2-Acetylpyridine
Details on test material:
- Name of test material (as cited in study report): 2-Acetylpyridine
- Molecular formula (if other than submission substance): C7H7NO
- Molecular weight (if other than submission substance): 121.138 g/mole
- Substance type: Organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Acetylpyridine
- Molecular formula (if other than submission substance): C7H7NO
- Molecular weight (if other than submission substance): 121.138 g/mole
- Substance type: Organic
- Physical state: solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2280 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 280 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 2280 mg//kg bw when rats were treated with 2-Acetylpyridine orally.
Executive summary:

In a acute oral toxicity study, rats were treated with 2-Acetylpyridine in the concentration of 2280 mg/kg bw orally. 50 % mortality was observed in treated rats. Therefore, LD50 was considered to be 2280 mg//kg bw when rats were treated with 2-Acetylpyridine orally.