Registration Dossier
Registration Dossier
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EC number: 203-620-1 | CAS number: 108-83-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Principles of method if other than guideline:
- no deviations from guideline
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- The Dow Chemical Company, Freeport, Texas (Lot# XA2355T643)
Non-GLP certificate of analysis indicates purity of > 99% as DIBK and DIBK isomers - Type:
- log Pow
- Partition coefficient:
- 3.71
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not relevant for HPLC method, as the substance is not ionizable
- Details on results:
- The Log Pow value for DIBK was estimated based on its chromatographic retention time in a standard HPLC assay following the OECD 117 guideline. The test substance eluted as a single chromatographic peak, having a retention time of 4.93 minutes, which correlates to an estimated log Pow of 3.71
- Conclusions:
- The Log Pow value for DIBK was estimated based on its chromatographic retention time in a standard HPLC assay following the OECD 117 guideline. The test substance eluted as a single chromatographic peak, having a retention time of 4.93 minutes, which correlated to an estimated log Pow of 3.71. Based on this value of log Pow, the substance is regarded as having low potential for accumulation in aquatic organisms.
- Executive summary:
The Log Pow value for DIBK was estimated based on its chromatographic retention time in a standard HPLC assay following the OECD 117 guideline. The test substance eluted as a single chromatographic peak, having a retention time of 4.93 minutes, which correlated to an estimated log Pow of 3.71. Based on this value of log Pow, the substance is regarded as having low potential for accumulation in aquatic organisms.
Reference
none
Description of key information
The partition coefficient for 2,6-dimethylheptan-4-one (diisobutyl ketone) is determined by the HPLC method to be 3.71.Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.71
- at the temperature of:
- 20 °C
Additional information
The Log Pow value for DIBK was estimated based on its chromatographic retention time in a standard HPLC assay following the OECD 117 guideline. The test substance eluted as a single chromatographic peak, having a retention time of 4.93 minutes, which correlated to an estimated log Pow of 3.71.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
