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EC number: 259-370-9 | CAS number: 54839-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 401)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethoxy-1-methylethyl acetate
- EC Number:
- 259-370-9
- EC Name:
- 2-ethoxy-1-methylethyl acetate
- Cas Number:
- 54839-24-6
- Molecular formula:
- C7H14O3
- IUPAC Name:
- 2-ethoxy-1-methylethyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Ethoxypropyl acetate
- Physical state: Liquid
- Analytical purity: >98.5%
- Storage condition of test material: At ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Each animal was identified by cage number and ear punching.
- Source: Interfauna UK Ltd., Huntingdon, Cambridgeshire, England
- Age at study initiation: Approximately 4 to 6 weeks
- Weight at study initiation: 100 to 127 g prior to dosing (Day 1) in the main study.
- Fasting period before study: Access to food only was prevented overnight prior to and approximately 4 hours after dosing.
- Housing: Animals were housed in groups by sex in metal cages with wire mesh floors.
- Diet: Ad libitum access to a standard laboratory rodent diet (Labsure LAD 1), except during the fasting period
- Water: Ad libitum access to tap water
- Acclimation period: A minimum of 5 days prior to start of the main study.
ENVIRONMENTAL CONDITIONS
- Temperature: The mean daily minimum and maximum temperature of the animal room were 21 degrees C and 23 degrees C.
- Humidity: The mean daily relative humidy value of the animal room was 63%.
- Air changes: Approximately 15 changes per hour.
- Photoperiod: 12 hours of artificial light in each 24 hour period.
IN-LIFE DATES: From: 20 August, 1985 To: 3 September, 1985
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED:
The test substance was administered as supplied at a constant volume of 5.3 ml/kg (specific gravity = 0.94).
CLASS METHOD (if applicable)
- Limit dose - Doses:
- 5 g/kg bodyweight
- No. of animals per sex per dose:
- Preliminary study – 2 males and 2 females
Main study – 5 males and 5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: Preliminary study – 5 days
Main study – 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing; then at frequent intervals for the remainder of Day 1. On subsequent days the animals were observed at least twice per day. Individual body weights were recorded on Days 1 (day of dosing), 8 and 15 of the main study.
- Necropsy of survivors performed: yes
- Other examinations performed: Clinical signs were recorded at each observation interval.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LDLo
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities.
- Clinical signs:
- Signs of reaction to treatment observed shortly after dosing in all rats were piloerection, hunched posture, abnormal gait (waddling), lethargy, pallor of the extremities and increased salivation.
- Body weight:
- All animals in the main study gained weight during the study period.
- Gross pathology:
- Terminal necropsy findings were normal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal oral dose to rats of ethoxypropyl acetate was greater than 5.0 g/kg bodyweight.
- Executive summary:
In a GLP and guideline acute oral toxicity study in rats, a single dose of ethoxypropyl acetate administered by gavage at the limit dose of 5.0 g/kg did not produce lethality.
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