Registration Dossier
Registration Dossier
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EC number: 201-368-7 | CAS number: 81-64-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of 1,4-dihydroxyanthraquinone to Daphnia magna was investigated in a semi-static test. After 48 hours of exposure an EC50 of > 0.134mg/L (geometric mean) was determined. No toxic effect was observed.
Key value for chemical safety assessment
Additional information
A study was performed to assess the acute toxicity 1,4-dihydroxyanthraquinone to Daphnia magna STRAUS under semi-static conditions. The study was conducted in accordance with the OECD Guideline for Testing of Chemicals No.202 'Daphnia sp., Acute Immobilisation Test'. A range finding test preceded the main test. It provided information about the range of concentrations which were used in the main test. The following nominal concentrations of the test item were tested in the range finding test: 1 and 10 mg/L. In the main test, Daphnia were exposed to the substance added to dilution water at a limit test concentration of nominally 10 mg/L for a period of 48 hours. At this concentration no toxic effects against Daphnia were observed at the end of the 48 hour study period. The obtained 48h-EC50 was > 0.134 mg/L. The result is expressed in term of geometric mean measured concentrations at 24 and 48 h. Effective concentrations ranged from 1.3 % to 3.3 % of nominal values in the freshly prepared media and from 0.7 % to 1.0 % of nominal values in the media after 24 hours of exposure. During the test a temperature range of 19.4 - 20.9 °C was maintained in the test vessels, with a maximum temperature fluctuation of +/- 1 °C in each individual test. The temperature, the pH and the oxygen values were measured every day in the freshly prepared media and in the media after 24 hours of exposure. This toxicity study is classified as acceptable and satisfies the guideline requirements for the acute Daphnia study.
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