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EC number: 219-616-8 | CAS number: 2481-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Short term toxicity to aquatic invertebrates:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Daphnia magna was predicted for 4-(Diethylamino)azobenzene (2481 -94 -9). The EC50 value was estimated to be 12.80 mg/l when 4-(Diethylamino) azo -benzene exposed to Daphnia magna for 48hrs.
Toxicity to aquatic algae and cyanobacteria:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)was predicted for 4-(Diethylamino)azobenzene (2481 -94 -9). The EC50 value was estimated to be 11.092mg/l when 4-(Diethylamino)azobenzene exposed to Desmodesmus subspicatus for 48hrs.
Additional information
Summarized result of the toxicity of 4-(Diethylamino)azobenzene (2481 -94 -9) on the growth and other activity of aquatic invertebrates and algae are as follows:
Short term toxicity to aquatic invertebrates:
Based on the various experimental data and prediction data for the target chemical and read across chemicals have been reviewed to determine the toxic nature of target chemical 4-(Diethylamino)azobenzene (2481 -94 -9). The studies are as mention below:
In the first weight of evidence study for 4-(Diethylamino)azobenzene (2481 -94 -9), Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Daphnia magna was predicted for 4-(Diethylamino)azobenzene (2481 -94 -9). The EC50 value was estimated to be 12.80 mg/l when 4-(Diethylamino) azo -benzene exposed to Daphnia magna for 48hrs.
Similarly in the second weight of evidence study for RA chemical (86 -30 -6), j-check. Acute Immobilization Test of N-Nitrosodiphenylamine to Daphnia magna. Test was performed in the static system in which different concentration 3.00, 5.40, 9.30, 18.0, 30.0 mg/L was taken. Nominal values were adopted for calculation of effect concentration, because all measurement concentrations of test Substance which were measured at the start of exposure and after 48 hours were within ±20 % of nominal values.). After 24 hrs, Median immobilization concentration (EiC50) was 13.5 mg/L (95 % CL: 9.30 – 18.0 mg/L), No observed effect concentration (NOECi): 9.30 mg/L. And Lowest concentration of 100 % inhibition was 30.0 mg/L. But after 48 hrs. Exposure no observed effect concentration (NOECi) was 3.00 mg/L. And the lowest concentration of 100 % inhibition: 18.0 mg/L. Based on the immobilization of daphnia magna, due to the N-Nitrosodiphenylamine, the EC50 was 10.1 mg/l
Similarly in the third weight of evidence study for the RA chemical (140 -56 -7) ecotox, Study of short term toxicity of N-[[4-(Dimethylamino) phenyl]imino] sulfamic acid sodium salt on the growth of invertebrates. The study was carried out in the static system for 24 hrs.Based on the mortality of Gammarus fasciatus due to the N-[[4-(Dimethylamino)phenyl]imino]sulfamic acid sodium salt dye to the 24 hrs exposure the LC50 was 18 mg/l. Based on the LC50, N-[[4-(Dimethylamino) phenyl]imino] sulfamic acid sodium saltchemical was toxic and can be consider to be not classified as per the CLP classification criteria.
Based on the various experimental data and prediction data for the target chemical and read across chemicals, 4-(Diethylamino)azobenzene (2481 -94 -9) was toxic and can be consider to be toxic and can be classified in aquatic chronic 3 category.
Toxicity to aquatic algae and cyanobacteria:
Based on the various experimental data and prediction data for the target chemical and read across chemicals have been reviewed to determine the toxic nature of target chemical 4-(Diethylamino)azobenzene (2481 -94 -9). The studies are as mention below:
In the first weight of evidence study for 4-(Diethylamino)azobenzene (2481 -94 -9), Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)was predicted for 4-(Diethylamino)azobenzene (2481 -94 -9). The EC50 value was estimated to be 11.092mg/l when 4-(Diethylamino)azobenzene exposed to Desmodesmus subspicatus for 48hrs.
Similarly in the second weight of evidence study for the RA chemical (119 -64 -2) tetralin, from OECD SIDS report and IUCLID dataset 2000.Toxicity of tetralin on the growth of freshwater algae Scenedesmus subspicatus for 72hrs was syudied. Test was performed in Erlenmeyer flasks in static system. 1 g test substance/l was stirred in deionized water for 18 hours and filtered. The resulting concentration was 63 mg/l. The maximum concentration tested was 17 mg/l. No vehicle or solvent was used. Toxicity was checked in the interval of 24 hrs, at Six different concentration 1.20; 2.0; 3.6; 6.0; 10.0; 17.0 mg/l (nominal) and 0 mg/l for control.Based on the growth rate of Scenedesmus subspicatus (Algae) due to the 1,2,3,4-Tetrahydronaphthalene the EC10, EC50, EC90 was 5.3 mg/l, 11 mg/l and 25 mg/l. But on the basis of of biomass the EC10, EC50, EC90 was 3.8 mg/l, 7mg/l, 13mg/l. and the NOEC was 3.6mg/l. Based on the EC50 (11 mg/l) growth rate of Scenedesmus subspicatus (Algae) due to the 1, 2, 3, 4-Tetrahydronaphthalene, chemical was toxic and can be consider in chronic category 3 as per the CLP classification criteria.
Based on the various experimental data and prediction data for the target chemical and read across chemicals 1, 2, 3, 4-Tetrahydronaphthalene, chemical was toxic to aquatic invertebrates and also algae and can be consider in chronic category 3 as per the CLP classification criteria.
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