Registration Dossier
Registration Dossier
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EC number: 219-616-8 | CAS number: 2481-94-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- REPORTS of the Scientific Committee on Cosmetology (seventh series).
- Author:
- COMMISSION OF THE EUROPEAN COMMUNITIES
- Year:
- 1 988
- Bibliographic source:
- Directorate-General Telecommunications, Information Industries and Innovation; Bâtiment Jean Monnet, LUXEMBOURG, 1988.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An ocular irritation study was performed on rabbits for test chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) to assess its eye irritating effects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(2,4-dimethylphenylazo)-2-naphthol
- EC Number:
- 221-490-4
- EC Name:
- 1-(2,4-dimethylphenylazo)-2-naphthol
- Cas Number:
- 3118-97-6
- Molecular formula:
- C18H16N2O
- IUPAC Name:
- 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol
- Details on test material:
- SMILES:Cc1ccc(N=Nc2c3ccccc3ccc2O)c(C)c1
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): C.I. Solvent orange 7
- Molecular formula: C18H16N2O
- Molecular weight : 276.337 g/mol
- Substance type: Organic
- Physical state: Solid
- Smiles : Cc1ccc(N=Nc2c(O)ccc3ccccc23)c(C)c1
- InChI: 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3/b20-19+
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100% (pure)
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Slight irritating effects were observed in treated rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) was considered to be slightly irritating to the eye of rabbits.
- Executive summary:
An ocular irritation study was performed on rabbits for test chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) to assess its eye irritating effects.
When pure1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol was administrated into the eye of rabbits, slight ocular effects were observed. Hence the chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) was considered to be irritating to the rabbits’ eye.
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