Crotonaldehyde

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: publication

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1984

Materials and methods

Type of study / information:

RD50

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Alaire 1966

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Crotonaldehyde

EC Number:

224-030-0

EC Name:

Crotonaldehyde

Cas Number:

4170-30-3

Molecular formula:

C4H6O

IUPAC Name:

but-2-enal

Details on test material:

Purchased from Aldrich Chemical Company, Milwaukee, Wisconsin
Purity 85-99 with the balance being water

Results and discussion

Any other information on results incl. tables

B6C3F1 mice exposed to crotonaldehyde showed a rapid decrease in respiratory rate at the onset of exposure which sustained throughout the exposure period with little or no recovery. RD50 10 min = 4.88 (4.0 -6.3) ppm. Swiss-Webster mice usually exhibted a continuously decreasing respiratory rate during the exposure period, especially at higher exposure concentrations. RD50 10 min = 3.53 (2.88 -4.62) ppm.

Applicant's summary and conclusion

Conclusions:

Swiss-Webster mice RD50 10 min = 3.53 (2.88 -4.62) ppm.

Executive summary:

3 -4 mice (B6C3F1 mice and swiss-webster mice) per group were exposured in a 2.7 liter head only exposure chamber for 10 min to concentrations of crotonaldehyde. Sensory irriation was quantified by measuring respiratory rate depression during these exposures. Respiratory rates were determined by a body plethysmographic method (Alaire 1966). The animals were sealed in an airtight body plethysmographs attached to the head only exposure chamber and allowed to acclimate for 10 min. Respiratory rates were recoreded during a 5 min preexposure, 10 min exposure, and 5 min recovery. The average maximum decrease in respiratory rate for 1 min was computed from the response of each gruop of animals and plotted versus the log of the exposure concentration. Usually 5 concentrations of aldehyde were used to construct a concentration response curve for which the RD50 (value at which there is a 50% decrease in respiratory rate) value was determined.

B6C3F1 mice exposed to crotonaldehyde showed a rapid decrease in respiratory rate at the onset of exposure which sustained throughout the exposure period with little or no recovery. RD50 10 min = 4.88 (4.0 -6.3) ppm. Swiss-Webster mice usually exhibted a continuously decreasing respiratory rate during the exposure period, especially at higher exposure concentrations. RD50 10 min = 3.53 (2.88 -4.62) ppm.