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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: no data available except for abstract. No details on study design, raw data, methods.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1982

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Crotonaldehyde
EC Number:
224-030-0
EC Name:
Crotonaldehyde
Cas Number:
4170-30-3
Molecular formula:
C4H6O
IUPAC Name:
but-2-enal
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
3 months
Frequency of treatment:
Continuous
Doses / concentrations
Remarks:
Doses / Concentrations:
1.2 mg/m3
Basis:
analytical conc.
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
LOAEL
Effect level:
1.2 mg/m³ air (analytical)
Sex:
not specified
Basis for effect level:
other: according to motor activity and blood hemoglobin levels

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Conclusions:
No enough data available to judge the applicability of the results. Crotonaldehdye is a highly irritating substance and in acute inhalation study excitation was seen noted often (excitation as in running around the cage, jumping - more than likely due to the irriation rather than any stimulatory effect). The change in hemoglobin levels is not reported in any other study with crotonaldehyde. This effect could also be attributed to the irritant potenetial of crotonaldehyde. No gross pathology or histology is available to confirm or explain this finding. No organ weights or other clinical parameters were reported in the abstract. This study is not valid for obtaining any inhalation parameters for crotonaldehyde.
Executive summary:

No enough data available to judge the applicability of the results. Crotonaldehdye is a highly irritating substance and in acute inhalation study excitation was seen noted often (excitation as in running around the cage, jumping - more than likely due to the irriation rather than any stimulatory effect). The change in hemoglobin levels is not reported in any other study with crotonaldehyde. This effect could also be attributed to the irritant potenetial of crotonaldehyde. No gross pathology or histology is available to confirm or explain this finding. No organ weights or other clinical parameters were reported in the abstract. This study is not valid for obtaining any inhalation parameters for crotonaldehyde.