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Diss Factsheets
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EC number: 914-468-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Year of publication: 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- The design of a diet restricted in saturated very long-chain fatty acids: therapeutic application in adrenoleukodystrophy
- Author:
- Van Duyn MA, Moser AE, Brown FR, Sacktor N, Liu A, Moser HW
- Year:
- 1 984
- Bibliographic source:
- The american Journal of Clinical Nutrition, 40: 277-284
Materials and methods
- Type of study / information:
- Concentrations of Very Long-Chain Fatty Acids (VLCFA) in common food are reported
The study was designed to create a diet restricted in VLCFA for adrenoleukodystrophy patients - Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- Determination of concentrations of VLCFA (C26:0) in 135 common foods and of C22:0 to C28:0 in VLCFA-unrestricted diets
- GLP compliance:
- no
Test material
- Reference substance name:
- very long-chain fatty acids
- IUPAC Name:
- very long-chain fatty acids
Constituent 1
Method
- Ethical approval:
- other: not necessary
- Details on study design:
- Food analysis: Samples of foods were emulsified and 1 g each was mixed with 110 ml of CHCl3/CH3OH (1/1 v/v). The mixture was centrifuged and aliqots of the supernatant were subjected to acid methanolysis. 4 µg of C27:0 methyl ester was added as internal standard. The sample was dried, rinsed twice with benzene and 1 N methanolic HCL was added. Methanolisation was performed overnight at 75 °C. Fatty acid methylesters were extracted with hexane and separated by thin layer chromatography. The spots were scraped of and analysed for the amount of VLCFA by capillary GLC.
All procedures were performed in duplicates - Exposure assessment:
- measured
Results and discussion
- Results:
- Range of concentrations for C26:0 in 135 common foods: 208.4 (peanut oil) to 0.001 (Hawaiian Punch) mg/100 g edible portion
VLCFA-content of a VLCFA-unrestricted diet (mg per daily portion):
C22:0: 253.8
C23:0: 9.4
C24:0: 115.9
C25:0: 3.4
C26:0: 14.8
C27:0: 0.3
C28:0: 0.4
Applicant's summary and conclusion
- Conclusions:
- The uptake of VLCFA (C22:0 to C28:0) in a VLCFA-unrestricted diet totals to about 450 mg per day.
- Executive summary:
Common foods were analysed for the content of VLCFA. The concentrations of C26:0 in 135 common foods ranged from 208.4 (peanut oil) to 0.001 (Hawaiian Punch) mg/100 g edible portion. The uptake of VLCFA (C22:0 to C28:0) via a VLCFA-unrestricted diet totals to about 450 mg/day VLCFA.
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