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Short-term toxicity to fish

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Description of key information

Juvenile Zebrafish were exposed in a 96 h static test according to OECD guideline 203 to aqueous test media containing the test item at various concentrations. A full dose response study - 100, 45.5, 20.7, 9.4 and 4.3 mg/L test item – was performed. The study encompassed 6 treatment groups (5 dose rates and a control) each containing 7 individuals. The recorded effects were mortality and sublethal effects on the fish.

In the control and at the concentrations up to 4.3 mg test item/L, all fish survived until the end of the experiment and no signs of intoxication occurred. At 9.4 mg/L one fish died and at 20.7 mg/L three fish died after 96 hours. At 45.5 mg/L two fish died and at 100 mg test item/L three fish died after 96 hours. Based on these test results the following dose descriptors were determined:

 

LC50 (96 h) > 100 mg/L

LOEC (96 h) = 20.7 mg/L

NOEC (96 h) = 9.4 mg/L

Key value for chemical safety assessment

Additional information