[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Guidance Document for using the OECD (Q)SAR Application Toolbox to develop Chemical Categories according to the OECD Guidance on Grouping of Chemicals

Author:

OECD Environment, Health and Safety Publications

Year:

2009

Bibliographic source:

Series on Testing and Assessment No. 102

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD QSAR Toolbox 4.1

Test material

Test material information

Constituent 1

Reference substance name:

[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate

EC Number:

201-036-1

EC Name:

[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate

Cas Number:

77-54-3

Molecular formula:

C17H28O2

IUPAC Name:

[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate

Results and discussion

Results of examinations

Details on results:

Predicted endpoint: LOEC, LOEL, NOAEL, NOEL, NOEL calculated; A/G↑, A/G↓, Abnormal Appearance,
Abnormal Behavior, Abnormal Body Position, Abnormal Breathing, Abnormal Fur, Abnormal Gait,
Abnormal Response in Handling, Abnormal Sensory Response, Absolute Organ Weight↑, Absolute
Organ Weight↓, Accumulation, Alb↑, Alb↓, ALP↑, ALP↓, ALT(GPT)↑, ALT(GPT)↓,
Anisonucleosis/Mitosis, Apoptosis/Necrosis, APTT↑, APTT↓, AST(GOT)↑, AST(GOT)↓, Atrophy, Atrophy
(necropsy), Atrophy Mucosa, Atrophy Pelvis, Atrophy Seminiferous, BASO↑, BASO↓, Basophilic
Change/Regeneration/Degeneration, Behavior, Bile Thrombus, Bilirubin↑, Bilirubin↓, Biochemistry,
Body Weight Changes, Body Weight↑, Body Weight↓, BUN↑, BUN↓, Calcium↑, Calcium↓, Castration
Cell↑, Casts, Cell Debris Germ Cell, Cell Hypertrophy, Cell Infiltration, Cell Infiltration/Inflamation,
Cell(s), Change in Globulin Fraction, Chloride↑, Chloride↓, Cl↑, Cl↓, Colloid↓, Coma, Congestion,
Creatinine↑, CT↑, CT↓, Cyanosis or Pale Skin, Death, Degeneration Epididymis, Degeneration Germ
Cell, Degeneration Nerve Fiber, Degeneration Semiferous Tubule, Degeneration Vacuolar,
Desquamation Tubular Epithelium Cell, Development, Diarrhea/Loose Stool/Bloody Stool, Dilatation,
Dilatation (necropsy), Discoloration, Edema, Emaciation, Enlarged, Enlarged (necropsy), Enzyme(s),
Eosinophilic Body/Hyaline Droplets, Eosinophilic Hepatocyte (Centrilobular), Eosinophilic Hepatocyte
(Other), Eosinophilic Hepatocyte (Periportal), EOSN↑, EOSN↓, Erosin, Extramedullary Hematopoiesis,
Fatty Change, Fatty Change/Vacuolization↑(Centrilobular), Fatty Change/Vacuolization↑(Other), Fatty
Change/Vacuolization↑(Periportal), Fatty Change/Vacuolization↓(Centrilobular), Fatty
Change/Vacuolization↓(Other), Fatty Change/Vacuolization↓(Periportal), Feeding Behavior,
Fibrinogen↑, Fibrinogen↓, Fibrosis, Foamy Cell Accumulation, Food Consumption↑, Food
Consumption↓, Genetics, Germ Cell↓, Glucose↑, Glucose↓, Growth, HCT↑, HCT↓, Hematopoiesis↑,
Hematopoiesis↓, Hemorrhage, HGB↑, HGB↓, Histology, Hormone(s), Hyperkeratosis/Parakeratosis,
Hyperplasia, Hyperplasia Epithlium, Hyperplasia Leydig Cell, Hyperplasia/hypertrophy,
Hyperplasia/Hypertrophy Follicular Cell, Hyperplasia/thickened Epithelial Cell, Hyperplasia/Thickneing
Epithelium, Hyperplasia/thicknening Epithelium, Hyperthermia, Hypertrophy, Hypertrophy Epithelium,
Hypertrophy/Swelling Hepatocyte (Centrilobular), Hypertrophy/Swelling Hepatocyte (Other),
Hypertrophy/Swelling Hepatocyte (Periportal), Hypothermia, I. Phosphorus↑, I. Phosphorus↓,
Immunological, Inflamation, Injury, K↑, K↓, Ketone Body↑, Ketone Body↓, Lacrimation, LDH↑, LDH↓,
Locomotor Activity↑, Locomotor Activity↓, LYMPH↑, LYMPH↓, MCH↑, MCH↓, MCHC↑, MCHC↓, MCV↑,
MCV↓, Mineralization, Miosis, MONO↑, MONO↓, Morphology, Mortality, Multinucleated Giant Cell,
Multiple Effects, Muscle Strength↓, Muscle Tone↓, Mydriasis, Myocardial Degeneration, Myocardial
Fibrosis, Myocardial Necrosis, Na↑, Na↓, Necrosis, Necrosis Germ Cell, Necrosis Hepatocyte
(Centrilobular), Necrosis Hepatocyte (Other), Necrosis Hepatocyte (Periportal), Nephropathy,
Neurological, NEUT↑, NEUT↓, Not Examined, Occult Blood, Organ Weight Changes, Other Findings,
Pathology, PH↑, PH↓, Physiology, Pigmentation (Hemosiderin), Pigmentation (Other), Piloerection,
PLT↑, PLT↓, Population, Potassium↑, Potassium↓, Proliferation, Proliferative, Protein↑, Protein↓, PT↑,
PT↓, Ptosis/Palpebral Closure, Pupillary Light Reflex, RBC↑, RBC↓, Relative Organ Weight↑, Relative
Organ Weight↓, Reproduction, Reproductive Effects, Retention Germ Cell, Reticulocyte↑,
Reticulocyte↓, Salivation, Sodium↑, Sodium↓, Specific Gravity↑, Specific Gravity↓, Straub Tail, T.
Bilirubin↑, T. Bilirubin↓, T. Cholesterol↑, T. Cholesterol↓, T. Protein↑, T. Protein↓, Teratogenic, Total,
Tremor/Convulsion, Triglyceride↑, Triglyceride↓, Tumorigen, Tumors, Ulcer, Urinary Sediment, Urine
Volume↑, Urine Volume↓, Urobilinogen↑, Urobilinogen↓, Vacuolization, Vacuolization Germ Cell,
Vacuolization Sertli Cell, Vocalization, Water Consumption↑, Water Consumption↓, WBC↑, WBC↓, Γ-
GTP↑, Γ-GTP↓; Bubalus bubalis, Canis familiaris, Capra sp., Mouse, Mus musculus, Oryctolagus
cuniculus, Ovis sp., Rat, Rattus norvegicus, Rattus rattus; No duration specified; No guideline
specified

Predicted value: 54.4 (from 0.32 to 9.23E+03)

Unit/scale: mg/kg bdwt/d

Data gap filling method: Trend analysis

Effect levels

Dose descriptor:

LOEL

Effect level:

ca. 54.4 mg/kg bw/day (nominal)

Based on:

test mat.

Basis for effect level:

body weight and weight gain

food consumption and compound intake

mortality

Target system / organ toxicity

Critical effects observed:

no