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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

short-term repeated dose toxicity: oral
Type of information:
Adequacy of study:
key study
2 (reliable with restrictions)

Data source

Reference Type:
Guidance Document for using the OECD (Q)SAR Application Toolbox to develop Chemical Categories according to the OECD Guidance on Grouping of Chemicals
OECD Environment, Health and Safety Publications
Bibliographic source:
Series on Testing and Assessment No. 102

Materials and methods

Test guideline
according to guideline
other: OECD QSAR Toolbox 4.1

Test material

Constituent 1
Chemical structure
Reference substance name:
[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
EC Number:
EC Name:
[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
Cas Number:
Molecular formula:
[3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate

Results and discussion

Results of examinations

Details on results:
Predicted endpoint: LOEC, LOEL, NOAEL, NOEL, NOEL calculated; A/G↑, A/G↓, Abnormal Appearance,
Abnormal Behavior, Abnormal Body Position, Abnormal Breathing, Abnormal Fur, Abnormal Gait,
Abnormal Response in Handling, Abnormal Sensory Response, Absolute Organ Weight↑, Absolute
Organ Weight↓, Accumulation, Alb↑, Alb↓, ALP↑, ALP↓, ALT(GPT)↑, ALT(GPT)↓,
Anisonucleosis/Mitosis, Apoptosis/Necrosis, APTT↑, APTT↓, AST(GOT)↑, AST(GOT)↓, Atrophy, Atrophy
(necropsy), Atrophy Mucosa, Atrophy Pelvis, Atrophy Seminiferous, BASO↑, BASO↓, Basophilic
Change/Regeneration/Degeneration, Behavior, Bile Thrombus, Bilirubin↑, Bilirubin↓, Biochemistry,
Body Weight Changes, Body Weight↑, Body Weight↓, BUN↑, BUN↓, Calcium↑, Calcium↓, Castration
Cell↑, Casts, Cell Debris Germ Cell, Cell Hypertrophy, Cell Infiltration, Cell Infiltration/Inflamation,
Cell(s), Change in Globulin Fraction, Chloride↑, Chloride↓, Cl↑, Cl↓, Colloid↓, Coma, Congestion,
Creatinine↑, CT↑, CT↓, Cyanosis or Pale Skin, Death, Degeneration Epididymis, Degeneration Germ
Cell, Degeneration Nerve Fiber, Degeneration Semiferous Tubule, Degeneration Vacuolar,
Desquamation Tubular Epithelium Cell, Development, Diarrhea/Loose Stool/Bloody Stool, Dilatation,
Dilatation (necropsy), Discoloration, Edema, Emaciation, Enlarged, Enlarged (necropsy), Enzyme(s),
Eosinophilic Body/Hyaline Droplets, Eosinophilic Hepatocyte (Centrilobular), Eosinophilic Hepatocyte
(Other), Eosinophilic Hepatocyte (Periportal), EOSN↑, EOSN↓, Erosin, Extramedullary Hematopoiesis,
Fatty Change, Fatty Change/Vacuolization↑(Centrilobular), Fatty Change/Vacuolization↑(Other), Fatty
Change/Vacuolization↑(Periportal), Fatty Change/Vacuolization↓(Centrilobular), Fatty
Change/Vacuolization↓(Other), Fatty Change/Vacuolization↓(Periportal), Feeding Behavior,
Fibrinogen↑, Fibrinogen↓, Fibrosis, Foamy Cell Accumulation, Food Consumption↑, Food
Consumption↓, Genetics, Germ Cell↓, Glucose↑, Glucose↓, Growth, HCT↑, HCT↓, Hematopoiesis↑,
Hematopoiesis↓, Hemorrhage, HGB↑, HGB↓, Histology, Hormone(s), Hyperkeratosis/Parakeratosis,
Hyperplasia, Hyperplasia Epithlium, Hyperplasia Leydig Cell, Hyperplasia/hypertrophy,
Hyperplasia/Hypertrophy Follicular Cell, Hyperplasia/thickened Epithelial Cell, Hyperplasia/Thickneing
Epithelium, Hyperplasia/thicknening Epithelium, Hyperthermia, Hypertrophy, Hypertrophy Epithelium,
Hypertrophy/Swelling Hepatocyte (Centrilobular), Hypertrophy/Swelling Hepatocyte (Other),
Hypertrophy/Swelling Hepatocyte (Periportal), Hypothermia, I. Phosphorus↑, I. Phosphorus↓,
Immunological, Inflamation, Injury, K↑, K↓, Ketone Body↑, Ketone Body↓, Lacrimation, LDH↑, LDH↓,
Locomotor Activity↑, Locomotor Activity↓, LYMPH↑, LYMPH↓, MCH↑, MCH↓, MCHC↑, MCHC↓, MCV↑,
MCV↓, Mineralization, Miosis, MONO↑, MONO↓, Morphology, Mortality, Multinucleated Giant Cell,
Multiple Effects, Muscle Strength↓, Muscle Tone↓, Mydriasis, Myocardial Degeneration, Myocardial
Fibrosis, Myocardial Necrosis, Na↑, Na↓, Necrosis, Necrosis Germ Cell, Necrosis Hepatocyte
(Centrilobular), Necrosis Hepatocyte (Other), Necrosis Hepatocyte (Periportal), Nephropathy,
Neurological, NEUT↑, NEUT↓, Not Examined, Occult Blood, Organ Weight Changes, Other Findings,
Pathology, PH↑, PH↓, Physiology, Pigmentation (Hemosiderin), Pigmentation (Other), Piloerection,
PLT↑, PLT↓, Population, Potassium↑, Potassium↓, Proliferation, Proliferative, Protein↑, Protein↓, PT↑,
PT↓, Ptosis/Palpebral Closure, Pupillary Light Reflex, RBC↑, RBC↓, Relative Organ Weight↑, Relative
Organ Weight↓, Reproduction, Reproductive Effects, Retention Germ Cell, Reticulocyte↑,
Reticulocyte↓, Salivation, Sodium↑, Sodium↓, Specific Gravity↑, Specific Gravity↓, Straub Tail, T.
Bilirubin↑, T. Bilirubin↓, T. Cholesterol↑, T. Cholesterol↓, T. Protein↑, T. Protein↓, Teratogenic, Total,
Tremor/Convulsion, Triglyceride↑, Triglyceride↓, Tumorigen, Tumors, Ulcer, Urinary Sediment, Urine
Volume↑, Urine Volume↓, Urobilinogen↑, Urobilinogen↓, Vacuolization, Vacuolization Germ Cell,
Vacuolization Sertli Cell, Vocalization, Water Consumption↑, Water Consumption↓, WBC↑, WBC↓, Γ-
GTP↑, Γ-GTP↓; Bubalus bubalis, Canis familiaris, Capra sp., Mouse, Mus musculus, Oryctolagus
cuniculus, Ovis sp., Rat, Rattus norvegicus, Rattus rattus; No duration specified; No guideline

Predicted value: 54.4 (from 0.32 to 9.23E+03)

Unit/scale: mg/kg bdwt/d

Data gap filling method: Trend analysis

Effect levels

Dose descriptor:
Effect level:
ca. 54.4 mg/kg bw/day (nominal)
Based on:
test mat.
Basis for effect level:
body weight and weight gain
food consumption and compound intake

Target system / organ toxicity

Critical effects observed:

Applicant's summary and conclusion