Registration Dossier
Registration Dossier
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EC number: 201-036-1 | CAS number: 77-54-3
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Guidance Document for using the OECD (Q)SAR Application Toolbox to develop Chemical Categories according to the OECD Guidance on Grouping of Chemicals
- Author:
- OECD Environment, Health and Safety Publications
- Year:
- 2 009
- Bibliographic source:
- Series on Testing and Assessment No. 102
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD QSAR Toolbox 4.1
Test material
- Reference substance name:
- [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
- EC Number:
- 201-036-1
- EC Name:
- [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
- Cas Number:
- 77-54-3
- Molecular formula:
- C17H28O2
- IUPAC Name:
- [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- LOEL
- Effect level:
- ca. 55.8 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- clinical signs
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- LOEL
- Generation:
- F1
- Effect level:
- ca. 55.8 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- clinical signs
Overall reproductive toxicity
- Reproductive effects observed:
- no
Any other information on results incl. tables
Predicted endpoint: LOEL, NOAEL; No effect specified; Oryctolagus cuniculus, Rabbit, Rat, Rattus
norvegicus; No duration specified; No guideline specified
Predicted value: 55.8 (from 2.16 to 1.44E+03)
Unit/scale: mg/kg bdwt/d
Data gap filling method: Read-across analysis
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
