Methyl non-2-enoate

Endpoint summary

Description of key information

Acute oral toxicity:

LD50 was considered to be > 5000 mg/kg bw when rat were treated with Methyl non-2-enoate orally.

Acute dermal toxicity:

LD50 was considered to be > 5000 mg/kg bw when rabbits were treated with Methyl non-2-enoate dermally. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed document

Qualifier:

according to guideline

Guideline:

other: Reefer below principle

Principles of method if other than guideline:

Acute oral toxicity study of methyl non-2-enoate in rat

GLP compliance:

not specified

Test type:

other: No data

Limit test:

no

Specific details on test material used for the study:

- Name of test material (as cited in study report): METHYL NONYLENATE
- Molecular formula (if other than submission substance): C10H18O2
- Molecular weight (if other than submission substance): 170.25 g/mole
- Substance type: Organic
- Physical state: Colorless liquid

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

5000 mg/kg

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Preliminary study:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality observed

Mortality:

No mortality observed at 5000 mg/kg bw in treated rat.

Clinical signs:

not specified

Body weight:

not specified

Gross pathology:

not specified

Other findings:

not specified

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

LD50 was considered to be > 5000 mg/kg bw when rat were treated with Methyl non-2-enoate orally.

Executive summary:

In acute oral toxicity study,rat were treated with Methyl non-2-enoate orally in the concentration of 5000 mg/kg bw. No mortality observed at 5000 mg/kg bw in treated rat. Therefore, LD50 was considered to be > 5000 mg/kg bw when rat were treated with Methyl non-2-enoate orally.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Quality of whole database:

Data is Klimisch 2 and from peer reviewed journal

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Quality of whole database:

Data is Klimisch 2 and from peer reviewed journal

Additional information

Acute oral toxicity:

In different studies, Methyl non-2-enoate has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for Methyl non-2-enoate along with the study available on structurally similar read across substance Hexyl acrylate (CAS no 2499-95-8). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In a experimental study summarized byOpdykeet al(Food and Cosmetics Toxicology, 14,811, 1976), rat were treated with Methyl non-2-enoate orally in the concentration of 5000 mg/kg bw. No mortality observed at 5000 mg/kg bw in treated rat. Therefore, LD50 was considered to be > 5000 mg/kg bw when rat were treated with Methyl non-2-enoate orally.

 

In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for Methyl non-2-enoate. The LD50 was estimated to be 2044 mg/kg bw when Wistar male and female rats were orally exposed with Methyl non-2-enoate.

Further supported by experimental study conducted by Smyth et al (American Industrial Hygiene Association Journal, Vol. 30, Pg. 470, 1969) on structurally similar read across substance Hexyl acrylate (CAS no 2499-95-8), rats were treated with Hexyl acrylate orally. 50 % mortality observed in treated rats at 23066 mg/kg bw. Therefore, LD50 was considered to be 23066 mg/kg bw (16783-31790) when rat were treated with Hexyl acrylate orally.

This is further supported by experimental study conducted by Bar et al (Food and Cosmetics Toxicology. 12, 815, 1974) on structurally similar read across substance Acetate C-8 (CAS no 112-14-1), rats were treated with Acetate C-8 in the concnetration of 3000 mg/kg orally. 50 % morality was observed in treated rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.

Thus, based on the above studies and predictions on Methyl non-2-enoate and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Methyl non-2-enoate can be classified as category V of acute oral toxicity.

Acute dermal toxicity:

In different studies, Methyl non-2-enoate has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for Methyl non-2-enoate along with the study available on structurally similar read across substance Hexyl acrylate (CAS no 2499-95-8). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

 In a experimental study summarized byOpdykeet al(Food and Cosmetics Toxicology, 14,811, 1976), rabbits were treated with Methyl non-2-enoate dermally in the concentration of 5000 mg/kg bw. No mortality observed at 5000 mg/kg bw in treated rat. Therefore, LD50 was considered to be > 5000 mg/kg bw when rabbits were treated with Methyl non-2-enoate dermally. 

 

In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for Methyl non-2-enoate. The LD50 was estimated to be 2433 mg/kg bw when rabbits were dermally exposed with Methyl non-2-enoate.

Further supported by experimental study conducted by Smyth et al (American Industrial Hygiene Association Journal, Vol. 30, Pg. 470, 1969) on structurally similar read across substance Hexyl acrylate (CAS no 2499-95-8), rabbits were treated with Hexyl acrylate dermally. 50 % mortality observed in treated rabbits at 5026 mg/kg bw. Therefore, LD50 was considered to be 5026 mg/kg bw (3108-8116) when rabbits were treated with Hexyl acrylate dermally.

This is further supported by experimental study conducted by Bar et al (Food and Cosmetics Toxicology. 12, 815, 1974) on structurally similar read across substance Acetate C-8 (CAS no 112-14-1), rabbits were treated with Acetate C-8 in the contrition of 5000 mg/kg dermally. No morality was observed in traded rabbits at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.

Thus, based on the above studies and predictions on Methyl non-2-enoate and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Methyl non-2-enoate can be classified as category V of acute dermal toxicity.

Justification for classification or non-classification

Based on the above studies and predictions on Methyl non-2-enoate and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Methyl non-2-enoate can be classified as category V of acute oral and dermal toxicity.