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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
review article or handbook
Title:
2-Ethylhexylacrylat [MAK Value Documentation in German language, 2007].
Author:
The MAK Collection for Occupational Health and Safety.
Year:
2012
Bibliographic source:
2-Ethylhexylacrylat [MAK Value Documentation in German language, 2007]; The MAK Collection for Occupational Health and Safety. 1–24, 2012.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
An eye irritation test of 2-Ethylhexyl acrylate (CAS No: 103-11-7) was performed in rabbits to assess its eye irritation potential according to OECD Test Guideline 405.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl acrylate
EC Number:
203-080-7
EC Name:
2-ethylhexyl acrylate
Cas Number:
103-11-7
Molecular formula:
C11H20O2
IUPAC Name:
2-(R,S)ethylhexyl acrylate
Test material form:
liquid
Details on test material:
- Name of test material: 2-Ethylhexyl acrylate
- Molecular formula: C11H20O2
- Molecular weight: 184.277g/mol
- Smiles notation: C([C@@H](CCCC)CC)OC(C=C)=O
- InChl: 1S/C11H20O2/c1-4-7-8-10(5-2)9-13-11(12)6-3/h6,10H,3-5,7-9H2,1-2H3
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: 2-Ethylhexyl acrylate
- Molecular formula: C11H20O2
- Molecular weight: 184.277g/mol
- Smiles notation: C([C@@H](CCCC)CC)OC(C=C)=O
- InChl: 1S/C11H20O2/c1-4-7-8-10(5-2)9-13-11(12)6-3/h6,10H,3-5,7-9H2,1-2H3
- Substance type: Organic
- Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Amount:0.1ml
Concentration applied:100%
Duration of treatment / exposure:
3 days
Observation period (in vivo):
24, 48 and 72 hours
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
TEST SITE
- Area of exposure: conjunctival sac of rabbits

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 3 d
Score:
0
Max. score:
110
Reversibility:
not fully reversible within: 3 days
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Only slight changes were observed. The average values after 24, 48 and 72 hours for the cornea were 0/0 / 0.3; For the iris 0/0 / 0.3; For mucous redness 0.3 / 0 / 0.3 as well as for mucous membrane curl 0/0 / 0.3. All results were completely reversible after 3 days.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test material of 2-Ethylhexyl acrylate (CAS No: 103-11-7) was considered to be not irritating to the eye of rabbits.
Executive summary:

An eye irritation test of 2-Ethylhexyl acrylate (CAS No: 103-11-7) was performed in rabbits to assess its eye irritation potential according to OECD Test Guideline 405.

 

About 0.1ml of undiluted 2-Ethylhexyl acrylate was installed into the one of each animal and the observations were made at 24, 48 h and 3 days after treatment.

 

Only slight changes were observed. The average values after 24, 48 and 72 hours for the cornea were 0/0 / 0.3; For the iris 0/0 / 0.3; For mucous redness 0.3 / 0 / 0.3 as well as for mucous membrane curl 0/0 / 0.3. All results were completely reversible after 3 days.

 

Since all the observed effects were cleared within 3 days, the chemical 2-Ethylhexyl acrylate (CAS No: 103-11-7) was considered to be non-irritant to the eyes of rabbits.