Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed document

Data source

Reference
Reference Type:
publication
Title:
METHYL NONELYNATE
Author:
D.L.J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology 14, 811

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Human maximization test was conducted on 25 volunteers to assess the sensitization potential of test chemical Methyl nonylenate (CAS no: 111-79-5).
GLP compliance:
not specified
Type of study:
other: Human maximization test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl non-2-enoate
EC Number:
203-908-7
EC Name:
Methyl non-2-enoate
Cas Number:
111-79-5
Molecular formula:
C10H18O2
IUPAC Name:
methyl non-2-enoate
Test material form:
liquid
Details on test material:
- Name of test material: methyl (2E)-non-2-enoate
- Molecular formula: C10H18O2
- Molecular weight: 170.25 g/mol
- Smiles notation: C(\C=C\C(OC)=O)CCCCC
- InChl: 1S/C10H18O2/c1-3-4-5-6-7-8-9-10(11)12-2/h8-9H,3-7H2,1-2H3/b9-8+
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: methyl (2E)-non-2-enoate
- Molecular formula: C10H18O2
- Molecular weight: 170.25 g/mol
- Smiles notation: C(\C=C\C(OC)=O)CCCCC
- InChl: 1S/C10H18O2/c1-3-4-5-6-7-8-9-10(11)12-2/h8-9H,3-7H2,1-2H3/b9-8+
- Substance type: Organic
- Physical state: Liquid

In vivo test system

Test animals

Species:
human
Strain:
other: not applicable
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Study design: in vivo (non-LLNA)

Induction
Route:
intradermal and epicutaneous
Vehicle:
petrolatum
Concentration / amount:
20%
Day(s)/duration:
No data available
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
20%
Day(s)/duration:
48 hours
Adequacy of challenge:
not specified
No. of animals per dose:
25 volunteers
Details on study design:
No data available
Challenge controls:
No data available
Positive control substance(s):
not required

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Hours after challenge:
48
Group:
test chemical
Dose level:
20%
No. with + reactions:
0
Total no. in group:
25
Clinical observations:
No skin sensitizing effects were observed.
Remarks on result:
no indication of skin sensitisation

In vivo (LLNA)

Cellular proliferation data / Observations:
No skin sensitizing effects were observed.

Applicant's summary and conclusion

Interpretation of results:
other: not sensitising
Conclusions:
The test material Methyl nonylenate (CAS no: 111-79-5) was considered to be not sensitizing to the skin of human subjects.
Executive summary:

Human maximization test was conducted on 25 volunteers to assess the sensitization potential of test chemical Methyl nonylenate (CAS no: 111-79-5).

 

The subjects were exposed to the chemical at concentration of 20% in petrolatum under 48 hours closed patch test.

 

None of the volunteers produced any contact allergic reaction. Hence the chemical Methyl nonylenate (CAS no: 111-79-5) was considered as non sensitizing to the skin of human subjects.