Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2005
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
α,4-dibromotoluene
EC Number:
209-636-5
EC Name:
α,4-dibromotoluene
Cas Number:
589-15-1
Molecular formula:
C7H6Br2
IUPAC Name:
α,4-dibromotoluene

In vivo test system

Test animals

Species:
mouse
Strain:
CBA/Ca
Sex:
not specified

Results and discussion

In vivo (LLNA)

Results
Parameter:
SI
Value:
>= 12 - <= 22
Test group / Remarks:
Considered sensitiser under conditions of test

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria