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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
other: database
Title:
Allyl Alcohol [CAS 107-18-6]
Author:
HSDB (Hazardous Substances Database), U.S. National Library of Medicine
Year:
2005
Bibliographic source:
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Reference Type:
publication
Title:
No information
Author:
Gorshtein ES et al
Year:
1978
Bibliographic source:
Eksp Med (Riga) 3: 15-20, cited in Ally Alcohol HSDB

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl alcohol
EC Number:
203-470-7
EC Name:
Allyl alcohol
Cas Number:
107-18-6
Molecular formula:
C3H6O
IUPAC Name:
prop-2-en-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Doses:
1 ml/100 g bw

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: cytochrome p450 increase, etc.
Effect level:
1 other: ml/100 g bw

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Acute Exposure/ Three hr after oral administration to rats of 1 ml/100 g body weight of allyl alcohol, cytochrome p450 was increased by 33% in liver microsomes. Aminopyrine demethylase and dimethylaniline demethylase were stimulated. Activity of microsomal hydroxylation system gradually decreased.