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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
The toxicity of allyl alcohol
Author:
Dunlap, M.K., Kodama, J.K., Wellington, J.S., Anderson, H.H., Hine, C.H.
Year:
1958
Bibliographic source:
AMA Archives of Industrial Health. 18:303-311

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not applicable
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl alcohol
EC Number:
203-470-7
EC Name:
Allyl alcohol
Cas Number:
107-18-6
Molecular formula:
C3H6O
IUPAC Name:
prop-2-en-1-ol
Details on test material:
- Analytical purity: 98.5%
- Impurities (identity and concentrations): diallyl ether and water

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male

Administration / exposure

Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 1 - <= 8 h
Concentrations:
95-5450 mg/m3 (nominal).
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
1 900 - 2 130 mg/m³ air
Based on:
test mat.
Exp. duration:
1 h
Sex:
male
Dose descriptor:
LC50
Effect level:
300 - 330 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC50
Effect level:
140 - 150 mg/m³ air
Based on:
test mat.
Exp. duration:
8 h

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed.
The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.
Executive summary:

Rats (Long-Evans; 6 males/group) were exposed for 1, 4 or 8 hours to allyl alcohol at concentrations between 95-5450 mg/m³ (nominal). Coma and diarrhoea were observed. On histopathological examination, toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed. The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.