Registration Dossier
Registration Dossier
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EC number: 203-470-7 | CAS number: 107-18-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Encyclopedia Of Toxicology, Four-Volume Set, Second Edition: 1-4
- Author:
- Philip Wexler
- Year:
- 2 005
- Bibliographic source:
- Encyclopedia Of Toxicology, Four-Volume Set, Second Edition: 1-4, Phylip Wexler, Academic Press, 2005
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- prop-2-en-1-ol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 1.5 mmol/kg
- Control animals:
- not specified
Results and discussion
Effect levels
- Remarks on result:
- other: development of hemolysis in ~50% of the animals
Applicant's summary and conclusion
- Conclusions:
- Intraperitoneal administration of 1.5 mmol/kg bw of allyl alcohol to starved Swiss albino mice causes the development of hemolysis in ~50% of the animals.
Other toxic effects include renal necrosis, pulmonary edema, and central nervous system effects at higher dose levels.
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