Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24-Sept-2009/01-Nov-2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: by loss of weight or by trapping vaporisate

Test material

Constituent 1
Test material form:
solid
Details on test material:
Test ITEM : LCE08115 (SEPIFEEL ONE)
Batch N° : 826900020
The test item consist in a mix of palmitoyl proline, magnesium palmitoyl glutamate and sodium palmitoyl sarcosinate (CAS N°59441-32-6, CAS N°57539-47-6, CAS N°4028-10-8).

The specimen was shipped at room temperature on behalf of Mr Olivier DENNY from DEFITRACES
It was treated according to the ANADIAG procedure PG 0204 for receipt, identification and storage.
The characteristics of the transport, of the receipt and of the storage in ANADIAG facilities were all registered and are summarised in the following table.
Table of shipment and storage:
Sample n°: LCE08115 Batch N° 826900020
Anadiag n°: 1480/A
Temperature during the transportation: Room temperature
Transportation date: 11.09.09
Date of receipt at the test facility: 14.09.09
Amount received: 90g
Condition of specimen upon receipt: Ok
Storage temperature: Room temperature

The maximum temperature was daily recorded and was below 30 °C during the storage period
The test item was stored away from moisture and direct light.
The sample was submitted to the test as received.
Specific details on test material used for the study:
Name SEPIFEEL ONE
Batch no. 826900020
Appearance beigeswhite granules
Composition palmitoyl proline, magnesium palmitoylglutamate, sodium
palmitoylsarcosinate
CAS NO. unknown
EINECS-NO. unknown
Molecular formula not stated
Molecular weight Purity Homogeneity Vapour pressure Solubility
Production date Expiry date Stability
Storage Hazard information Risk phrases Safety phrases
327 g/mol (based on N-palmitoyl sarcosinate)
mot Stated
not Stated
not stated water 0.1 - 1 g/L, ethanol 1 g/L, acetone, acetonitril, DMSO unknown
unknown
25.09.2011
unknown
room temperature 20 it 5°C, dark

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
1.31 other: mPa
Temp.:
25 °C
Vapour pressure:
1.67 other: mPa
Transition / decomposition
Transition / decomposition:
yes
Remarks:
LIQUEFACTION
Transition temp.:
60 °C

Applicant's summary and conclusion

Conclusions:
Vapour pressure at 20°C: 1.31 * 10E-3Pa
Vapour pressure at 25 °C: 1.67 * 10E-3 Pa
Executive summary:

Title of Study:

Determination of the Vapour Pressure of SEPIFEEL ONE according to OECD 104 resp. EU A.4 by the effusion method (weight loss).

Findings and Results:

The vapour pressure of SEPIFEEL ONE was determined following EU A.4 by the effusion method (weight Ioss). The vapour pressure was determined at ten different temperatures. Five temperatures showed significant and reproducible weight loss. For these ternperatures, l/T was plotted against Log P.

 Experiment

 T

 P

 Stand. Dev. P

 RSD P

No. 

 K

 Pa

 Pa

 %

 4

 342.3

 9.87E-03

 2.79E-03

 28.2%

 5

 356.4

 1.98E-02

 4.00E-03

 20.2%

 6

 370.5

 2.27E-02

 1.30E-02

 57.3%

8

 398.7

 4.90E-02

 8.47E-03

 17.3%

 9

 412.9

 9.68E-02

 3.10E-02

 32.1%

The graph l/T vs. log P shows a straight une with a correlation coefficient of - 0.9835.

For the test item SEPIFEEL ONE, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 1.31 * 10 -3 Pa

Vapour pressure at 25 °C: 1.67 * 10 -3 Pa

SEPIFEEL ONE is a mixture of compounds and no pure chemical substance, the estimated values belong to the compound with the lowest boiling point.