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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

There are no in vivo data on the toxicokinetics of trichloro(vinyl)silane. The following summary has therefore been prepared based on validated predictions of the physicochemical properties of the substance itself and its hydrolysis products. Trichloro(vinyl)silane is a moisture-sensitive, volatile liquid that hydrolyses rapidly in contact with water (half-life ca. <1 minute at pH 7), generating HCl and vinylsilanetriol. Human exposure can occur via the inhalation or dermal routes. Relevant inhalation exposure would be to the hydrolysis products (hydrolysis would occur rapidly when inhaled, even if a mixture of parent and hydrolysis products were present in air). The substance would also hydrolyse rapidly in contact with moist skin. The resulting HCl hydrolysis product would be severely irritating or corrosive.

Absorption

Oral: Significant oral exposure is not expected for this corrosive substance.

Dermal: The molecular weights of the parent and hydrolysis products favour absorption across the skin. However, the very high predicted water solubility (1,000,000 mg/l) and low predicted log Kow(-2.01) of the hydrolysis product, vinylsilanetriol, suggest that it is too hydrophilic to cross the lipid rich stratum corneum. Therefore dermal uptake is likely to be low. Since the other hydrolysis product, HCl is corrosive to the skin; damage to the skin might increase penetration. The only available reliable dermal toxicity study did not reveal any signs of systemic dermal toxicity.

Inhalation: The high water solubility of vinylsilanetriol might lead to some of this hydrolysis product being retained in the mucous of the lungs. As with dermal exposure, damage to membranes caused by the corrosive nature of the HCl hydrolysis product might enhance the uptake. In the available acute inhalation toxicity studies the only adverse effects appeared to be secondary to corrosive effects of the test substance.

Distribution

All absorbed material is likely to be in the form of the hydrolysis products, vinylsilanetriol and HCl. The hydrophilic nature of vinylsilanetriol will limit its diffusion across membranes (including the blood-brain and blood-testes barriers) and its accumulation in fatty tissues. Hydrogen and chloride ions will enter the body’s natural homeostatic processes.

Metabolism

Trichloro(vinyl)silane is rapidly hydrolysed to vinylsilanetriol and HCl in the presence of moisture. Most if not all of this will have occurred before absorption into the body. There are no data regarding the metabolism of vinylsilanetriol. Genetic toxicity tests in vitro showed no observable differences in effects with and without metabolic activation for trichloro(vinyl)silane.

Excretion

The low molecular weight and high water solubility of vinylsilanetriol suggest that it is likely to be rapidly eliminated via the kidneys in urine. There is therefore no evidence to suggest that this substance will accumulate in the body.