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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study pre-dated GLP and OECD guidelines. The original reference was not available for review.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
other: non data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(vinyl)silane
EC Number:
200-917-8
EC Name:
Trichloro(vinyl)silane
Cas Number:
75-94-5
Molecular formula:
C2H3Cl3Si
IUPAC Name:
trichloro(vinyl)silane
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
1.26, 0.63, and 0.315 ml/kg
No. of animals per sex per dose:
5/group at two highest dose levels; 4/group at lowest dose level (sex not specified)
Control animals:
no
Details on study design:
Undiluted vinyltrichlorosilane was applied to the skin of three groups of male rabbits (5/group at the two highest doses; 4/group at lowest dose) of doses of 1.26, 0.63 and 0.315 g/kg. The contact period was 24 hours under an occlusive "Vinylite" sheeting.  Clinical signs of toxicity and body weight change were recorded over a 14 day period.
Statistics:
Calculation of R.F. LD50 was done by the method of Thompson.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
0.68 mL/kg bw
95% CL:
0.48 - 0.94
Gross pathology:
This compound is so corrosive on rabbit skin that perforation of the abdominal wall occurs with dosages of 0.316 ml/kg and greater. 

Any other information on results incl. tables

Number of deaths at each dose level:

Sex

Dose level

(mL/kg)

Dead/Dosed

Weight Change in 14 days in survivors (g)

Not specified

1.26

5/5

Not applicable

0.63

2/5

-42, -500, -510

0.316

0/4

-130, -142, -396, +62

A 100% mortality was assumed for a dosage level of 2.52
ml/kg and 100% survival for 5 rabbits at 0.316 ml/kg for
calculation of R.F. LD50 by the method of Thompson.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a pre-GLP and pre-guideline study, the dermal LD50 of trichloro(vinyl)silane in male rabbits was 0.68 ml/kg.