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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient details to determine reliability. The original report was not available for review.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Principles of method if other than guideline:
Method: not reported
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(vinyl)silane
EC Number:
200-917-8
EC Name:
Trichloro(vinyl)silane
Cas Number:
75-94-5
Molecular formula:
C2H3Cl3Si
IUPAC Name:
trichloro(vinyl)silane
Details on test material:
No purity could be found.

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
other: open or semi-occlusive covering
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
No data
Duration of treatment / exposure:
Exposure durations were 2, 10, 15 and 30 minutes.
Details on study design:
The test material was applied undiluted to the skin of a rabbit under conditions of cotton covering or no covering.

Results and discussion

In vivo

Irritant / corrosive response data:
No effect to slight hyperemia was observed under conditions of no covering. Slight hyperemia was observed following a 2 minute exposure with cotton covering. Slight edema, hyperemia and necrosis were observed following 10 and 15 minutes exposures under conditions of cotton covering. Slight edema, hyperemia and severe necrosis were observed following the 30 minute exposure with cotton covering.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
Undiluted vinyltrichlorsilane has a severe effect upon intact skin.