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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The result is sourced from secondary literature (IUCLID 2000 data set). The original reference was not available for review and no further information is available.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Reference Type:
publication
Title:
No information
Author:
Zavarova, TS and Epshtein, AB
Year:
1973
Bibliographic source:
Gig. Tr. Prof. Zabol., 17, 36-39 cited in IUCLID 2000

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Type of study:
open epicutaneous test

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(vinyl)silane
EC Number:
200-917-8
EC Name:
Trichloro(vinyl)silane
Cas Number:
75-94-5
Molecular formula:
C2H3Cl3Si
IUPAC Name:
trichloro(vinyl)silane
Details on test material:
No data

In vivo test system

Test animals

Species:
human
Strain:
other: Not applicable
Sex:
not specified
Details on test animals and environmental conditions:
Not applicable

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: Not applicable
Vehicle:
other: toluene
Concentration / amount:
0.02-0.08% solution
Challengeopen allclose all
Route:
epicutaneous, open
Vehicle:
other: toluene
Concentration / amount:
0.02-0.08% solution
No. of animals per dose:
Ten workers
Details on study design:
Not applicable
Challenge controls:
The vehicle was also tested as a negative control.
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: overall result
Clinical observations:
No sensitising effect
Remarks on result:
other: Reading: other: overall result. Clinical observations: No sensitising effect.

Applicant's summary and conclusion

Conclusions:
In an IUCLID 2000 human skin sensitisation study summary trichloro(vinyl)silane was not sensitising to the skin. The original report was not available for review.
Executive summary:

In an open epicutaneous test, solutions of trichloro(vinyl)silane (0.02 -0.08% in toluene) were applied to the skin of ten workers in the optical glass industry for 24 -48 hours; control tests were conducted with the vehicle. Workers had been occupationally exposed (handling of 0.02 -0.08% solutions of trichlorovinylsilane in toluene and additionally with solutions of mercury acetate in methanol) for approximately five years before testing. Under the conditions of this study the test substance was not a skin sensitiser.