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EC number: 200-917-8 | CAS number: 75-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2008-09-02 TO 2008-09-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
- EC Number:
- 218-747-8
- EC Name:
- Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
- Cas Number:
- 2224-33-1
- IUPAC Name:
- butan-2-one O,O',O''-(vinylsilanetriyl)oxime
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, Frederick, MD, USA,
- Age at study initiation: 6 weeks
- Weight at study initiation: Males: 27.4 – 31.0 g; Females: 24.6 – 29.0 g
- Assigned to test groups randomly: yes
- Fasting period before study: no
- Housing: up to five per rodent Micro-Barrier cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: corn oil
- Justification for choice of solvent/vehicle: good solubility/workability of the test article in the vehicle and compatability with the test system and route of administration.
- Concentration of test material in vehicle: stock concentration of 200 mg/ml wasdiluted to give doses used, at a constant volume of 10 ml/kg - Frequency of treatment:
- Single treatment
- Post exposure period:
- 24 or 48 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1000, 1300, 1600 and 1800 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5/sex/group
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- - cyclophosphamide
- Justification for choice of positive control(s): none given in report - standard control
- Route of administration: IP
- Doses / concentrations: (50 mg/kg) bw
Examinations
- Tissues and cell types examined:
- Bone marrow
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION: BAsed on a ppilot toxicity study followed by a toxicity study
TREATMENT AND SAMPLING TIMES ( in addition to information in specific fields): 24 and 48 hours post-dose
DETAILS OF SLIDE PREPARATION: cells were washed, resuspended, fixed on glass slides with methanol, stained with May-Gruenwald-Giemsa stain
METHOD OF ANALYSIS: light microsocope - area selected at x400, analysis performed at x 1000
2000 PCEs scored for presence of micronuclei; incidence of NCEs, ( normochromatic erythrocytes), MNCEs (micronucleated normochromatic erythrocytes) and total erythrocytes, and the incidence of MNCEs per 2000 PCEs was enumerated, but not presented in report.
OTHER: - Evaluation criteria:
- The test article would have been considered to induce a positive response if a dose responsive increase in the incidence of micronucleated polychromatic erythrocytes is observed and one or more doses are statistically elevated relative to the vehicle control (p≤ 0.05, Kastenbaum-Bowman Tables) at any sampling time.
The test article was judged negative if no statistically significant increase in micronucleated polychromatic erythrocytes above the concurrent vehicle control values and no evidence of dose response were observed at any sampling time. - Statistics:
- Kastenbaum-Bowman Tables
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- reduction in PCE/total erythrocytes in males at highest dose, 48 h exposure
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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